• Adults ≥18 years of age at the time of study consent

• Subjects with any of the following eligible solid tumor diagnoses as confirmed by cytology or histology:

‣ Escalation Cohorts (Part A): Subjects with advanced solid tumors from pre-specified tumor types (Gynecological cancers \[including ovarian, fallopian, primary peritoneal, endometrial, cervical, vaginal, vulvar\], gastric \[adenocarcinoma\], Colorectal (\[MSIlow and CPI refractory MSIhigh\]), lung \[non-small cell lung adenocarcinoma and squamous cell carcinoma\] who are recurrent or refractory to platinum-based chemotherapy in addition to prior treatment with CPI Programmed Cell Death-1 (PD-1)/Programmed Cell Death-Ligand 1 (PD-L1) or who give informed consent to forego such therapy, renal \[clear cell and non-clear cell\], breast \[TNBC and HR+ HER-2-\] with locally advanced or metastatic disease that is relapsed or refractory to at least one line of post-adjuvant therapy (including a CPI-either alone or in combination if approved for that indication, and not eligible for other targeted therapies specific for their tumor type).

⁃ Expansion Cohorts (Part B): Subjects with advanced solid tumors selected from 5 prespecified cancers based on preclinical and Part A.

• Subjects must provide an original, diagnostic tumor sample to determine TREM2 expression (sites have verified source prior to screening and availability of archival tissue during screening). Subjects without an archival tissue sample will only be eligible if they choose and consent to provide a CNB of primary or a metastatic lesion required for part B, used in Part A only if an archival specimen unavailable.

• Subjects must have documented disease progression (including prior treatment with a CPI (alone or in combination), if approved for that indication.

• There is no limit to the number of prior treatments.

• Measurable disease by RECIST 1.1

• All acute toxic effects of any prior antitumor therapy, including immunotherapy, have resolved to Grade \< 2 before the start of study drug dosing (including Grade \< 2 alopecia or peripheral neuropathy, or if controlled on thyroid replacement therapy).

• Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) ≤ 2

• Coagulation: International Normalized Ratio (INR) ≤ 1.3, unless on a therapeutic anticoagulant

• Adequate hematologic function defined as follows: Platelets ≥ 100 x 10\^9/L; Hemoglobin ≥ 8.0 g/dL; ANC ≥ 1.5 x 10\^9/L (without granulocytic growth factors within the previous 7 days of obtaining the screening hematologic laboratory values)

• Adequate hepatic function defined as follows: AST / ALT ≤ 2.5 x upper limit of normal (ULN) (if liver metastases are present, ≤ 5 x ULN); Total or conjugated bilirubin ≤ 1.5 x ULN

• Adequate renal function defined as follows: Serum Creatinine ≤ 2 x ULN or creatinine clearance (CrCl) ≥45 mL/min as calculated by the Cockroft-Gault method