Genetic and Epigenetic Background of Inner Ear Dysfunction in Turner Syndrome

Status: Recruiting
Location: See location...
Study Type: Observational
SUMMARY

The goal of this case-control study is to pave the way for new revolutionary treatment measures within hearing loss that could either replace or delay the need for hearing aids. The study focuses on people with Turner syndrome (TS). The aim is to find out if there are specific DNA methylation patterns and/or RNA expression profiles linked to sensorineural hearing loss (SNHL) in people with TS. Additionally, the structure and function of the inner ear in these individuals will be examined to see if there is a connection to their epigenetic profile. The main question it aims to answer is: Does epigenetics constitute a common denominator for some of the unexplained SNHL cases? Turner Syndrome (TS) represents an ideal model for studying epigenetics related to sensorineural hearing loss (SNHL). Participants will undergo the following tests: * Ear examinations * Hearing tests * Balance tests * Blood tests * MRI scans * CBCT (cone-beam computed tomography) scans

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 60
Healthy Volunteers: t
View:

• age between 18 and 60 years old

Locations
Other Locations
Denmark
ENT department of Gødstrup Hospital
RECRUITING
Herning
Contact Information
Primary
Louise Hill-Madsen, MD
lohill@rm.dk
20282635
Time Frame
Start Date: 2025-02-01
Estimated Completion Date: 2027-07-30
Participants
Target number of participants: 150
Treatments
Group 1
Individuals with TS and SNHL
Group 2
Individuals with TS without SNHL
Group 3
Healthy age matched controls without TS and without SNHL
Sponsors
Leads: Gødstrup Hospital
Collaborators: University of Aarhus, Aarhus University Hospital

This content was sourced from clinicaltrials.gov