Immune Function and the Progression to Type 1 Diabetes:
Status: Recruiting
Location: See all (3) locations...
Intervention Type: Other
Study Type: Observational
SUMMARY
To elucidate the mechanisms by which type 1 diabetes-associated genes; IFIH1, TYK2, IKZF4, as well as total genetic risk, impart functional immunoregulatory abnormalities that result in expansion of self-reactive adaptive immune cells, defective regulatory/effector mechanisms in T cells, inflammatory antigen presenting cells, and abnormal immune function in T cells and B cells.
Eligibility
Participation Requirements
Sex: All
Maximum Age: 100
Healthy Volunteers: t
View:
Locations
United States
Florida
Kieran McGrail
RECRUITING
Gainesville
Ohio
The Ohio State University
RECRUITING
Columbus
Texas
Baylor College of Medicine, Center for Research Advancement - Texas Children's Hospital
RECRUITING
Houston
Contact Information
Primary
Jennifer L Hosford, MPH
jennifer.hosford@peds.ufl.edu
352-294-5759
Backup
Kieran McGrail
mcgrail@pathology.ufl.edu
(352) 273-9299
Time Frame
Start Date: 2005-01-01
Estimated Completion Date: 2085-01-01
Participants
Target number of participants: 2800
Treatments
Subjects with diabetes age 0 to 100 years
People who have not been diagnosed with type 1 diabetes
Subjects with type 1 diabetes age 0 to 100 years
People who have been diagnosed with type 1 diabetes
Related Therapeutic Areas
Sponsors
Collaborators: National Institute of Allergy and Infectious Diseases (NIAID), Juvenile Diabetes Research Foundation
Leads: University of Florida