Type 1 Diabetes, Endothelin, and Skeletal Muscle Mitochondrial Dysfunction: The Role of Sirtuin-1
Who is this study for? Adult patients with Type 1 Diabetes
What treatments are being studied? Resveratrol
Status: Recruiting
Location: See location...
Intervention Type: Other, Drug
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY
The proposed study is designed to test the hypothesis that treatment of resveratrol for 12 weeks will improve both endothelin-B receptor (aim 1) and skeletal muscle mitochondrial function (aim 2) in people with type 1 diabetes.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• Men and premenopausal women
• All races
• Clinical diagnosis of insulin-dependent type 1 diabetes (patients only)
Locations
United States
Georgia
Augusta University/Georgia Prevention Institute/ Laboratory of Integrative and Exercise Physiology
RECRUITING
Augusta
Contact Information
Primary
Ryan A Harris, PhD, CEP
ryharris@augusta.edu
7067215998
Backup
Jacob Looney, MS
jlooney@augusta.edu
7067215483
Time Frame
Start Date: 2020-10-14
Estimated Completion Date: 2027-07-01
Participants
Target number of participants: 24
Treatments
Experimental: Individuals with type 1 diabetes
Individuals with type 1 diabetes will be randomly assigned to 1 of the 2 interventions (Resveratrol or placebo)
No_intervention: Healthy Controls
Healthy individuals who participate will receive no intervention and serve as controls.
Related Therapeutic Areas
Sponsors
Leads: Augusta University