INTERPLAY WITHIN THE DAY: Optimizing Intra-day Glucose Control by Intervening on the Day-to-day 24-hour Movement Behavior Patterns in Adults With Type 1 Diabetes Mellitus.

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Behavioral
Study Type: Observational
SUMMARY

Only 24.9% of the Belgian adults (25-50 years) with type 1 diabetes mellitus (T1DM) achieve a good glucose control. This can be explained by the challenging day-to-day diabetes management which places a substantial burden on this population. However, a tight glycemic control is fundamental in order to prevent the development of acute and chronic complications. Despite the added value of continue glucose monitors to glucose control, optimizing daily glucose levels is still problematic in adults with T1DM. In addition to self-monitoring of blood glucose, a healthy lifestyle with sufficient physical activity (PA), limited sedentary behavior (SB) and sufficient sleep time and quality is crucial for a good glucose control. A recent shift in health promotion stresses the importance of considering all these behaviors (i.e. PA, SB and sleep) in one 24-hour day instead of focusing on one behavior in isolation. The aim of this study is to investigate the association between the day-by-day 24h-MB patterns of adults (25-50 years) with T1DM and their intra-day glucose control (i.e. time in range and coefficient of variation) on the one hand. On the other hand, associations between he 24-h MB patterns and explanatory variables and cardiometabolic health markers will be investigated. To gain insight into the 24-hour behavior of adults with type 1 diabetes, 150 adults with type 1 diabetes will wear an Actigraph accelerometer, for 14 consecutive days. Daily glucose control will be measured using the participant's continuous glucose meter. Information about the explanatory variables and cardiometabolic health will be obtained by means of a questionnaire, diary and a few measurements (blood pressure, weight, length, Advanced Glycation Endproducts, hip-and waist circumference) during a one-off visit to one of the recruitment- and testing centers namely University hospital of Ghent or University hospital of Antwerp. The results of this cross-sectional study will inform future interventions focusing on the 24-hour movement behaviors in adults with T1DM.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 25
Maximum Age: 50
Healthy Volunteers: f
View:

• Adults between 25 and 50 years

• Diagnosed with T1DM for a minimum of two years

• Minimal daily insulin dose of 10 units

• Using a continuous glucose monitor

• Most recent HbA1c between 6% and 9.5%

Locations
Other Locations
Belgium
University Hospital Antwerp
RECRUITING
Antwerp
University Hospital Ghent
RECRUITING
Ghent
Contact Information
Primary
Lotte Bogaert, PhD
Lotte.Bogaert@ugent.be
093323638
Backup
Marieke De Craemer, Professor
Marieke.Decraemer@ugent.be
09 332 52 08
Time Frame
Start Date: 2024-05-23
Estimated Completion Date: 2025-12
Participants
Target number of participants: 150
Treatments
Adults with type 1 diabetes
Adults with type 1 diabetes (25-50 years) will wear an accelerometer to objectively measure their 24-hour movement behaviors. An online questionnaire and food diary will be completed to gain insight into the explanatory variables of 24-hour movement behaviors. Information on glucose control will be collect through the continuous glucose monitor of the participant.
Related Therapeutic Areas
Sponsors
Collaborators: University Ghent
Leads: University Hospital, Ghent

This content was sourced from clinicaltrials.gov