The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.

Eligibility
Participation Requirements
Sex: All
Healthy Volunteers: t
View:

• 55 years and older, 18-40 years old

• Healthy, physically active, performing at least 90 min/week of physical activity

• Free of physical limitations that may interfere with alterations in daily physical activity levels

Locations
United States
Virginia
Old Dominion University
RECRUITING
Norfolk
Contact Information
Primary
Leryn Reynolds
lreynold@odu.edu
757-683-4974
Time Frame
Start Date: 2022-07-25
Estimated Completion Date: 2025-04-01
Participants
Target number of participants: 40
Treatments
Experimental: Metabolic
Metabolic: Participants will have their blood glucose levels measured via continuous glucose monitoring for 3 days while participating in their normal exercise routines (EX). Participants will also have their blood glucose levels measured for 3 days while not exercising (NOEX), following immediately by 3 days of a return to normal activity(REX). Participants will be randomized to participate in the EX or NOEX/REX phases first. The EX and NOEX/REX phases will be separated by at least 1 week
Experimental: Vascular
Vascular: Participants will have their blood vessel health measured while performing their normal exercise routines (EX) and while undergoing 1, 3, 5 days of no exercise (NOEX) followed immediately by 1 and 3 days of return to exercise (REX).
Related Therapeutic Areas
Sponsors
Leads: Old Dominion University

This content was sourced from clinicaltrials.gov