Determining Circadian Metabolic and Behavioural Rhythms in Patients with and Without Type 2 Diabetes and Identifying the Relation to Hormone and Glucose Fluctuations, and Cognition
The goal of the present clinical descriptive study is to characterize and quantify the potential hormonal chronobiological differences between individuals with type 2 diabetes (T2D) and healthy age and weight-matched controls as either circadian aligned or misaligned. The investigators hypothesize that individuals with T2D have a misaligned and different circadian rhythmicity of circadian biomarkers (melatonin and cortisol) than controls, and that this difference in turn is related to 24h hormonal fluctuations, behaviour, and metabolic-, cardiac-, and cognitive parameters. Participants will be asked to: * fill-out a diary on eating and sleeping habits for 30 days * wear an actigraphy and continuous glucose monitor for 10-14 days * stay overnight at the research facility, including continuous blood sampling and polysomnography
⁃ Individuals with T2D:
• Informed and written consent.
• Clinically diagnosed diabetes mellitus type 2 for at least 5 years (diagnosed according to criteria of World Health Organization (WHO)).
• HbA1c \>53 mmol/mol
• Stable medical treatment for at least 8 weeks.
• Plasma haemoglobin ≥8.00 mmol/L (male) or ≥6.4 mmol/L (female).
• Male or female participants aged 50-75 years.
⁃ Healthy matched controls:
• Informed and written consent.
• Normal haemoglobin ≥8.00 mmol/L (male) or ≥6.4 mmol/L (female).
• Male or female participants aged 50-75 years.