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Uppsala Self-Screening of Cardiovascular Health: A Randomized Controlled Trial of Home-Based Multimodal Cardiovascular Screening Versus Usual Care in Middle-Aged and Older Adults

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

U-SCREEN is a randomized controlled trial evaluating whether systematic home-based multimodal screening for cardiovascular risk conditions, offered to residents in Region Uppsala turning 50, 55, 60, 65, 70 or 75 years of age, can identify clinically actionable cardiovascular risk factors more effectively than usual care. Participants randomized to the screening arm receive a home blood pressure measurement device, a dried blood spot sampling kit (for ApoB, HbA1c and creatinine), and a digital questionnaire. The control arm receives usual care. Recruitment runs 2024-2027 with a target identification of 10,000 cardiovascular risk conditions.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 75
Healthy Volunteers: t
View:

• Resident in Region Uppsala, Sweden

• Turning 50, 55, 60, 65, 70 or 75 years during recruitment period

• Able to provide informed consent

Locations
Other Locations
Sweden
Uppsala University Hospital
RECRUITING
Uppsala
Contact Information
Primary
Johan Sundström, MD, PhD
johan.sundstrom@uu.se
+46 70 422 52 20
Time Frame
Start Date: 2025-02-01
Estimated Completion Date: 2037-12
Participants
Target number of participants: 45000
Treatments
Experimental: Screening
Home cardiovascular screening package: 7-day home BP measurement; dried blood spot self-sampling for ApoB, HbA1c and creatinine; digital questionnaire on lifestyle, symptoms, family history, diagnoses, medications. Above-threshold findings trigger initiation of guideline-recommended pharmacotherapy and referral to clinical care.
No_intervention: Control
Usual care. No active screening offered as part of trial. Outcomes via national register and EHR linkage.
Sponsors
Leads: Johan Sundström
Collaborators: Region Uppsala

This content was sourced from clinicaltrials.gov