Type 2 Diabetes (T2D) Clinical Trials

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Efficacy and Safety of Once-weekly Subcutaneous UBT251 in Participants With Type 2 Diabetes - a Dose-finding Study

Status: Recruiting
Location: See all (70) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

The study is testing UBT251 in participants with type 2 diabetes. The purpose of this clinical study is to find out if UBT251 is effective and safe for treating participants with type 2 diabetes. Participants will either get UBT251, UBT251 placebo, semaglutide, or semaglutide placebo. Which treatment participants get is decided by chance. UBT251 is the treatment being tested and is not yet available for doctors to prescribe, while semaglutide is a medicine used to treat type 2 diabetes that doctors can already prescribe.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:

• Male or female (sex assigned at birth, inclusive of all gender identities).

• Age 18-75 years (both inclusive) at the time of signing the informed consent.

• Diagnosed with type 2 diabetes greater than or equal to (≥) 180 days before screening.

• Stable daily dose(s) ≥ 90 days before screening of the following antidiabetic drug(s) or combination regimen(s) at effective or maximum tolerated dose as judged by the investigator:

⁃ metformin with or without sodium-glucose cotransporter-2 (SGLT2) inhibitor.

• HbA1c of 7.0-10.5 percent (%) (53-91 millimoles per mole (mmol/mol)) (both inclusive) as assessed by central laboratory at screening.

• Body mass index between 25.0 kg/m\^2 and 50.0 kg/m\^2 (both inclusive) at screening.

Locations
United States
Alabama
Flourish Research
RECRUITING
Birmingham
California
Ark Clinical Research
RECRUITING
Fountain Valley
Ark Clinical Research
RECRUITING
Long Beach
Los Angeles Institute for Metabolic Research
RECRUITING
Los Angeles
Catalina Research Institute, LLC
RECRUITING
Montclair
Florida
Encore Medical Research LLC
RECRUITING
Hollywood
South Broward Research LLC
RECRUITING
Miramar
Encore Medical Research of Weston
RECRUITING
Weston
Indiana
Midwest Inst For Clin Res
NOT_YET_RECRUITING
Indianapolis
Kansas
Cotton O'Neil Diabetes & Endocrinology
RECRUITING
Topeka
Maryland
MD Medical Research
RECRUITING
Oxon Hill
North Carolina
PharmQuest
NOT_YET_RECRUITING
Greensboro
KDCILM, LLC & Accellacare US, Inc.
RECRUITING
Wilmington
North Dakota
Plains Clinical Research Center, LLC_Fargo
NOT_YET_RECRUITING
Fargo
Pennsylvania
Preferred Primary Care Physicians, Inc.
RECRUITING
Uniontown
South Carolina
Monroe Biomedical Research, LLC
RECRUITING
North Charleston
Tennessee
LifeDoc Health
RECRUITING
Memphis
Texas
IMA Clinical Research
RECRUITING
Austin
Private Practice - Dr. Laila A. Hassan
RECRUITING
Houston
Radiance Clinical Research
RECRUITING
Lampasas
Quality Research Inc
RECRUITING
San Antonio
Tekton Research Inc
RECRUITING
San Antonio
Consano Clin Res-Shavano Park
RECRUITING
Shavano Park
Utah
Chrysalis Clinical Research
RECRUITING
St. George
Washington
The Vancouver Clinic
NOT_YET_RECRUITING
Vancouver
Other Locations
Australia
Royal Adelaide Hospital - Cardiology Department
RECRUITING
Adelaide
Castle Hill Medical Centre
RECRUITING
Castle Hill
Novatrials
NOT_YET_RECRUITING
Charlestown
Baker Heart and Diabetes Institute
RECRUITING
Melbourne
Hunter Medical Research Institute - Endocrinology and Diabetes
NOT_YET_RECRUITING
New Lambton Heights
Roger Chih Yu Chen
RECRUITING
Sydney
Germany
Versdias - Diabetologikum Amberg
NOT_YET_RECRUITING
Amberg
Herz- und Diabeteszentrum NRW - Bad Oeynhausen
NOT_YET_RECRUITING
Bad Oeynhausen
Medizinisches Versorgungszentrum Am Bahnhof Spandau GbR
NOT_YET_RECRUITING
Berlin
DSP Bochum, Diabetes- und Stoffwechselpraxis
NOT_YET_RECRUITING
Bochum
Studiengesellschaft Dres. Könemann/Steinmann GbR
NOT_YET_RECRUITING
Bünde
InnoDiab Forschung GmbH
NOT_YET_RECRUITING
Essen
Mesut Durmaz, Hof
NOT_YET_RECRUITING
Hof
CRS Clinical Research Mannheim GmbH (hVIVO Mannheim)
NOT_YET_RECRUITING
Mannheim
Hungary
PVN Kutató Kft.
NOT_YET_RECRUITING
Budapest
Semmelweis Egyetem
NOT_YET_RECRUITING
Budapest
Szent Margit Rendelőintézet Nonprofit Kft.
NOT_YET_RECRUITING
Budapest
Pécsi Tudományegyetem ÁOK
NOT_YET_RECRUITING
Pécs
Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ
NOT_YET_RECRUITING
Szeged
Poland
NZOZ Vita-Diabetica Malgorzata Buraczyk
NOT_YET_RECRUITING
Bialystok
Uniwersytecki Szpital Kliniczny w Bialymstoku
NOT_YET_RECRUITING
Bialystok
Specjalistyczna Praktyka Lekarska Diabetologia, Leczenie Cukrzycy i Otyłości lek. Monika Piwowar
NOT_YET_RECRUITING
Kielce
1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ
NOT_YET_RECRUITING
Lublin
Clinical Best Solutions Sp. z o.o., Sp. k
NOT_YET_RECRUITING
Lublin
Formed 2 Sp. z o.o.
NOT_YET_RECRUITING
Oświęcim
Republic of Korea
Chosun University Hospital_Endocrinology
NOT_YET_RECRUITING
Gwangju
Asan Medical Center_Endocrinology
NOT_YET_RECRUITING
Seoul
Korea University Guro Hospital_Endocrinology
NOT_YET_RECRUITING
Seoul
The Catholic University of Korea, Seoul ST. Mary's Hospital_Endocrinology
NOT_YET_RECRUITING
Seoul
Romania
Mariodiab Clinic SRL
NOT_YET_RECRUITING
Brasov
SC Nutrilife SRL
NOT_YET_RECRUITING
Bucharest
S.C. Top Diabet Srl
NOT_YET_RECRUITING
Craiova
S.C Milena Sante SRL
NOT_YET_RECRUITING
Galati
Clinica Korall S.R.L. Satu Mare
NOT_YET_RECRUITING
Satu Mare
Spitalul Clinic Judetean De Urgenta Pius Brinzeu Timisoara
NOT_YET_RECRUITING
Timișoara
Slovakia
MEDISPEKTRUM s.r.o.
NOT_YET_RECRUITING
Bratislava
IN-DIA s.r.o.
NOT_YET_RECRUITING
Lučenec
MEDI-DIA s.r.o.
NOT_YET_RECRUITING
Sabinov
ARETEUS s.r.o.
NOT_YET_RECRUITING
Trebišov
Spain
Hospital Vall d'Hebron
NOT_YET_RECRUITING
Barcelona
Eap Osona Sud Alt Congost S.L.P
NOT_YET_RECRUITING
Centelles (barcelona)
Hospital Universitario de la Princesa
NOT_YET_RECRUITING
Madrid
H. Univ. Marqués de Valdecilla_Endocrinología
NOT_YET_RECRUITING
Santander
H. Infanta Luisa_Endocrino y Obesidad
NOT_YET_RECRUITING
Seville
Equip D'assistencia Primaria Vic S.L.P.
NOT_YET_RECRUITING
Vic
Contact Information
Primary
Novo Nordisk
clinicaltrials@novonordisk.com
(+1) 866-867-7178
Time Frame
Start Date: 2026-06-22
Estimated Completion Date: 2027-11-15
Participants
Target number of participants: 300
Treatments
Experimental: UBT251
Participants will receive once weekly UBT251 subcutaneously.
Placebo_comparator: UBT251 Placebo
Participants will receive once weekly UBT251 placebo subcutaneously.
Active_comparator: Semaglutide
Participants will receive once weekly semaglutide subcutaneously.
Placebo_comparator: Semaglutide Placebo
Participants will receive once weekly semaglutide placebo subcutaneously.
Related Therapeutic Areas
Sponsors
Leads: Novo Nordisk A/S

This content was sourced from clinicaltrials.gov