Quantifying Brown Adipose Tissue Thermogenesis in Type 2 Diabetes

Status: Recruiting
Location: See location...
Intervention Type: Drug, Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Activation of brown adipose tissue (BAT) by cold exposure. BAT thermogenesis and BAT volume of metabolic activity will be assessed by Positron-Emitting-Tomography (PET/CT) and MRI/MRS imaging and new pharmacological methods to modulate BAT thermogenesis. All previous data on the functioning of Brown Adipose Tissue (BAT) were obtained by Positron-Emitting-Tomography (PET) imaging studies using fluorodeoxyglucose F18 ( \[18F\]- FDG). This approach underestimates the actual activity of the BAT. In this study, the investigator is going to use a new PET tracer (C11-palmitate) which is a fat molecule. This will allow to quantify more accurately the activity of brown fat.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: t
View:

• 10 men and 10 women with T2D.

• 10 non-diabetic men and 10 non-diabetic women (matched for sex, BMI and age to the T2D participants).

Locations
Other Locations
Canada
Centre de recherche du CHUS
RECRUITING
Sherbrooke
Contact Information
Primary
Frédérique Frisch
frederique.frisch@Usherbrooke.ca
819-346-1110
Time Frame
Start Date: 2021-05-18
Estimated Completion Date: 2025-12
Participants
Target number of participants: 40
Treatments
Active_comparator: Subject with Type 2 Diabetes- cold exposure
3-hour cold exposure: Protocol B
Experimental: Subject with type 2 Diabetes- cold exposure and nicotinic acid
3-hour cold exposure with oral nicotinic acid: Protocol A
Active_comparator: Subject without Type 2 Diabetes- cold exposure
3-hour cold exposure: Protocol B
Experimental: Subject without type 2 Diabetes- cold exposure and nicotinic acid
3-hour cold exposure with oral nicotinic acid: Protocol A
Related Therapeutic Areas
Sponsors
Leads: Université de Sherbrooke

This content was sourced from clinicaltrials.gov