Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY

The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: * Does presence of Type 2 Diabetes reduce autophagy and impair microvascular function? * Does exposure to high glucose impair autophagy and subsequently microvascular function? Participants will undergo 2 study days. The primary outcome will be in vivo microvascular function testing. Following the first study day participants will undergo either supplementation with trehalose, an autophagy activator, or placebo for 14 days. The second study day will test in vivo microvascular function.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 80
Healthy Volunteers: t
View:

• Clinical Diagnosis of Type 2 Diabetes Mellitus in accordance with American Diabetes Association (ADA) guidelines (Type 2 Diabetic group)

• Otherwise healthy individuals (Healthy control group) with no more than 1 cardiovascular risk factor

Locations
United States
Wisconsin
Medical College of Wisconsin
RECRUITING
Milwaukee
Contact Information
Primary
William Hughes, Ph.D.
whughes@mcw.edu
414-955-7519
Time Frame
Start Date: 2023-01-01
Estimated Completion Date: 2029-12-31
Participants
Target number of participants: 60
Treatments
Experimental: Trehalose
10g mixed in 500 mL of water, consumed 1 time per day
Placebo_comparator: Placebo
10g microcrystalline cellulose in 500 mL, consumed 1 time per day
Related Therapeutic Areas
Sponsors
Leads: Medical College of Wisconsin

This content was sourced from clinicaltrials.gov