Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial
Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement, Other
Study Type: Interventional
Study Phase: Early Phase 1
SUMMARY
The majority of T2DM adults show thiamine (vitamin B1) deficiency which may contribute to impaired function. This study will examine patients with T2DM through brain MRI scans, cognition assessments, blood tests, and questionnaires. Our goal is to see if a thiamine treatment (taking vitamin B1 capsules) can improve function. Patients will be asked to come to UCLA two times three months apart and each visit will last about 2.5-3 hours.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 65
Healthy Volunteers: f
View:
• Diagnosed T2DM
• Outpatient status
• Able to lay flat for imaging
Locations
United States
California
UCLA
RECRUITING
Los Angeles
Contact Information
Primary
Rajesh Kumar, PhD
rkumar@mednet.ucla.edu
310-206-1699
Backup
Bhaswati Roy, PhD
broy@mednet.ucla.edu
310-206-6133
Time Frame
Start Date: 2024-08-01
Estimated Completion Date: 2026-04-30
Participants
Target number of participants: 52
Treatments
Experimental: BBB function, cognition, and mood in T2DM adults with Thiamine treatment.
Analyze BBB function, cognition, and mood in T2DM adults with Thiamine treatment and compare to the placebo group.
Placebo_comparator: BBB function, cognition, and mood in T2DM adults without Thiamine treatment.
Analyze BBB function, cognition, and mood in T2DM adults without Thiamine treatment and compare to the Thiamine treatment group.
Related Therapeutic Areas
Sponsors
Leads: University of California, Los Angeles
Collaborators: National Institute on Aging (NIA)