Mechanisms for Glucagon Resistance as Driver of Metabolic Associated Steatotic Liver Disease and Cardiovascular Disease in Humans With Type 2 Diabetes

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this clinical trial is to investigate the sensitivity to glucagon in patients with type 2 diabetes mellitus (T2DM), with and without metabolic associated fatty liver disease (MASLD). The main questions it aims to answer are: 1. Is the sensitivity to glucagon with respect to hepatic FA oxidation and suppression of VLDL-TG secretion impaired in humans with T2DM and MASLD? 2. Is glucagon resistance and MASLD reflected in an aberrated lipidomic/metabolomic profile in blood and adipose tissue? Researchers will compare patients with T2DM with and without MASLD to see if the response to basal and high levels of glucagon differs between the groups. Participants will attend 2 short visits and 1 full-day visit, including: * Body scan (DXA) to check fat and bone composition * MRI to measure liver fat. * Blood tests. * Ultrasound to check liver stiffness and scarring. * Fat biopsies * 8-hour hormone (including glucagon) and tracer infusion * PET-CT scans

Eligibility
Participation Requirements
Sex: All
Minimum Age: 30
Maximum Age: 70
Healthy Volunteers: f
View:

• BMI \> 26 kg/m²

• confirmed diagnosis of Type 2 Diabetes Mellitus (T2DM) min. 6 months prior enrollment

• steatosis FF% \> 5,6% on MR spectroscopy for MAFLD group

Locations
Other Locations
Denmark
Aarhus University Hospital
RECRUITING
Aarhus
Contact Information
Primary
Kia E. Fonfara, Medical Doctor
kia.eistrup@clin.au.dk
+4524607114
Time Frame
Start Date: 2026-01-01
Estimated Completion Date: 2028-07-31
Participants
Target number of participants: 24
Treatments
Active_comparator: Subjects with T2DM and MR spectroscopy verified NO steatosis
Active_comparator: Subjects with T2DM and MR spectroscopy verified steatosis
Sponsors
Leads: University of Aarhus
Collaborators: Novo Nordisk A/S

This content was sourced from clinicaltrials.gov