Efficacy and Safety of the Triple Combination Therapy of Met/SGLT-2i/GLP-1RA or Other Oral Antidiabetic Drugs in Patients With Type 2 Diabetes Exhibiting Poor Glycemic Control

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

The main objective of this study is to compare the efficacy and safety of the triple combination therapy of Met/SGLT-2i/GLP-1RA or other oral antidiabetic drugs in patients with type 2 diabetes exhibiting poor glycemic control.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:

• Meet the diagnostic criteria for type 2 diabetes (refer to the Chinese Guidelines for the Prevention and Treatment of Type 2 Diabetes (2020 edition)); -Age: 18-75 years old (including the threshold), male or female;

• Body mass index (BMI) ≥20kg/m² ;

• Patients who took 1000mg or more of metformin in combination with or without another oral hypoglycemic agent (except SGLT-2i and oral GLP-1RA) for at least 8 weeks before screening and had poor blood glucose control (centralized detection of HBA1C \>=7.5% and\<=11.0%);

• Volunteer to participate in this study and sign informed consent.

Locations
Other Locations
China
Tianjin Medical University General Hospital
RECRUITING
Tianjin
Contact Information
Primary
Xiaofen Qian
qianxiaofen@eastchinapharm.com
+86-0571-89908582
Backup
Wanting Zhang
zhangwanting@eastchinapharm.com
+86-0571-89905517
Time Frame
Start Date: 2025-03-29
Estimated Completion Date: 2028-06-30
Participants
Target number of participants: 430
Treatments
Experimental: Met+SGLT-2i+GLP-1RA
Metformin+Ganagliflozin+Liraglutide
Active_comparator: Triple Therapy of Other Oral Antidiabetic Drugs
Building upon the previously stable treatment regimen, the addition of 1-2 oral hypoglycemic agents (excluding SGLT-2 inhibitors and oral GLP-1 receptor agonists) constitutes a triple oral hypoglycemic regimen.
Related Therapeutic Areas
Sponsors
Leads: Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

This content was sourced from clinicaltrials.gov