Whey Protein Dose-response Effect on Daily Glycaemic Excursions in Very Old Individuals With Type 2 Diabetes
The goal of this placebo-controlled, partial crossover design study is to identify the impact of consuming whey protein before meals on free-living glucose control in older adults living with type 2 diabetes. The primary specific objective is to determine the effect of a thrice daily whey protein pre-meal supplementation at two doses, on glucose excursions over a 7-day free-living period in adults aged 75-90 years of age, living with type 2 diabetes, compared with a non-protein placebo. Participants will consume the whey protein and placebo for 7 days each, before each meal. All participants will consume the placebo and one of two doses of whey protein, in a randomised order.
• Male or female
• 75-90 years old
• Type 2 Diabetes (confirmed with glycated haemoglobin (HbA1c) \>6.5% in clinic or in SportExR)
• Stable body mass (body mass index (BMI) ≤40kg/m2)
• Generally healthy, assessed via a General Health Questionnaire (GHQ)
• Some residual beta-cell activity (confirmed with urine test on induction)
• Normal or moderately increased albuminuria (needs to be below 300mg/g)
• Normal, mildly or moderately decreased glomerular filtration rate (GFR) (needs to be above 45ml/min/1.732).
• Able and willing to attend SportExR a total of 5 times: 1 induction and 2 testing visits and 2 return check-up visits.