Nanjing First Hospital, Nanjing Medical University
The effects of Tirzepatide and Insulin Glargine on glucose and lipid metabolism and inflammation in patients with type 2 diabetes mellitus. Effects of Tirzepatide on the occurrence and development of cognitive impairment in diabetic patients and its associated pattern of changes in brain neural network characteristics.
• Type 2 diabetes was diagnosed according to World Health Organization(WHO) classification or other locally applicable diagnostic criteria.
• Received stable metformin with or without sulfonylureas at least 2 months prior to visit 1 and between visits 1 and 3 (metformin ≥ 1000 mg/ day and does not exceed the maximum dose specified in the nationally approved guidelines;Sulfonylureas should be at least half of the maximum dose as stated in the national approved instructions).
• No insulin treatment (except for gestational diabetes or short-term use in acute Settings \[duration ≤14 days\]).
• At visit 1, HbA1c ≥ 7.5% and ≤ 11.0% was determined according to the central laboratory.
• Body mass index (BMI) ≥ 23 kg/m2.