Autologous Adipose Tissue Derived Stromal Vascular Fraction Versus Cultured Adipose Derived Stem Cells for the Treatment of Chronic Diabetic Wounds
The aim of this study is to evaluate the therapeutic efficacy of uncultured adipose derived stromal vascular fraction (SVF) and cultured adipose derived stem cells (ASCs) both supplemented with platelet rich plasma (PRP) to treat chronic diabetic foot ulcers. It will increase the pragmatic potential of both types of cells as PRP is rich in survival and chemotactic factors. Moreover, the autologous nature of the proposed study will ensure safety of its use in diabetic patients and will unveil the more effective therapeutic option for treatment of foot ulcer wounds.
• Type 1 or Type 2 Diabetes Mellitus
• Age 20-60 years (Male/Female)
• Body mass index 20-30 kg/m2
• Suitable for liposuction
• Condition or Disease: Diabetic Neuropathy
• Wound Type: Chronic foot ulcer
• Approx. wound area: 2 cm2 - 8 cm2
• Wound Condition should be of Wagner's grade I (Limited to soft tissue)
• Duration of wound persistence: 6-24 Weeks
• Transcutaneous oxygen pressure \> 30 mmHg, and an ankle brachial pressure index \> 0.5.
• Already following an adequate off-loading method
• Provided signed informed consent