Department of Pharmacy, the Affiliated Hospital of Xuzhou Medical University
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This is a retrospective cohort study of patients with T2DM who were treated with exenatide twice daily as a part of their diabetes care for at least 12 months. The objective of this study is to investigate the influence of T2DM susceptibility gene polymorphisms (NOS1AP, KCNQ1, TCF7L2, WSF1, GLP-1R, etc.) on the efficacy of GLP-1 RA (exenatide, liraglutide, etc.), to identify the variables that can predict the efficacy of GLP-1 RA, and to evaluate the weight of these variables on the efficacy.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 25
Maximum Age: 70
Healthy Volunteers: f
View:
• a diagnosis of T2DM
• a body mass index (BMI) of 20-35 kg/m2
• an HbA1c of 7.0%-12%, an age of 25-70 years
• required data available at baseline and 6 months after GLP-1RA therapy.
Locations
Other Locations
China
China, Jiangsu, Department of Endocrinology
RECRUITING
Xuzhou
Contact Information
Primary
Tao Wang, Ph.D
misswt2011@126.com
13815344640
Backup
Xiaoxing Yin, Ph.D
yinxx@xzmc.edu.cn
13605218523
Time Frame
Start Date: 2024-01-01
Estimated Completion Date: 2028-01-31
Participants
Target number of participants: 300
Treatments
Experimental: efficacy difference of GLP-1RA
Responders group and non-responders group
Related Therapeutic Areas
Sponsors
Leads: The Affiliated Hospital of Xuzhou Medical University