The Influence of the Japanese washoku Diet on the Composition of the Gut Microbiota and Its Metabolites in Overweight or Obese Postmenopausal Women

Status: Recruiting
Location: See location...
Intervention Type: Dietary supplement
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Menopause is a special period in a woman's life, when a sudden drop in estrogen levels leads to the cessation of menstrual cycles. Hormonal changes and a decreasing metabolic rate contribute to weight gain and the appearance of numerous metabolic disorders, such as dyslipidemia, impaired glucose tolerance, insulin resistance, hyperinsulinemia, and type 2 diabetes. Currently, effective and inexpensive dietary therapeutic solutions are being sought to improve the health of this group of women. It is suggested that the Japanese washoku diet, which includes products rich in isoflavones, fiber (soy products) and unsaturated omega-3 fatty acids (fish, seaweed), may be a good solution, as it contributes to the regulation of hormonal balance, lowering cholesterol levels, and reducing the risk of insulin resistance. Moreover, the composition of such a diet may also affect the diversity of the intestinal microbiota and the production of its metabolites, such as short-chain fatty acids, and thus contribute to the improvement of patients' health. Taking the above into account, the aim of the study will be to assess the effect of the Japanese washoku diet on the composition of the intestinal microbiota and its metabolites in a group of overweight or obese women after natural menopause. Specific objectives: * Assessment of anthropometric parameters (body weight, height, waist circumference, hip circumference) and body composition and bone density. * Assessment of parameters of carbohydrate metabolism (glucose, insulin concentration), lipid metabolism (total cholesterol (T-C), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), non-HDL cholesterol (non-HDL-C) and triglycerides). * Analysis of intestinal microbiota, short-chain fatty acids in the feces of women.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 45
Maximum Age: 65
Healthy Volunteers: f
View:

• age 45 to 65,

• at least one year after natural menopause,

• BMI \> 25 kg/m2

• waist circumference \> 80 cm.

Locations
Other Locations
Poland
Poznań University of Life Sciences
RECRUITING
Poznan
Contact Information
Primary
Joanna Bajerska, Assoc. Prof.
Joanna.bajerska@up.poznan.pl
8466056
Backup
Joanna M. Pieczyńska-Zając, M.Sc.
joanna.pieczynska@up.poznan.pl
660 950 786
Time Frame
Start Date: 2024-11-16
Estimated Completion Date: 2027-11-12
Participants
Target number of participants: 40
Treatments
Experimental: Washoku diet
Participants assigned to the washoku group will be introduced to the principles of a healthy eating plate, which will be supplemented with elements of the washoku diet (30 g of roasted black soybeans and 5 g of wakame).
No_intervention: Control group
Participants assigned to the control group will receive only dietary recommendations consistent with the healthy eating plate.
Related Therapeutic Areas
Sponsors
Leads: Joanna Bajerska

This content was sourced from clinicaltrials.gov