Optimization and Evaluation of the Diagnosis and Treatment System for Diabetic Retinopathy in Type 2 Diabetes Mellitus

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

This study aims to integrate clinical indicators and features of fundus images, combined with metabolomics, to construct an early warning model for diabetic retinopathy (DR) in type 2 diabetes. By combining clinical indicators with metabolomics, the investigators aim to establish a precise DR typing model based on the age of diabetes onset (early-onset diabetes, late-onset diabetes) and based on the coexistence with two types of diabetic macrovascular complications. A multidisciplinary collaboration will be conducted for comprehensive management of DR to control the progression of moderate-stage DR. Cloud-based patient rooms combined with continuous glucose monitoring (CGM) will further explore the role of integrated diabetes retinopathy ward management models in the management of patients undergoing diabetes retinopathy surgery, pioneering a new model for the management of advanced DR.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 20
Maximum Age: 79
Healthy Volunteers: f
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• Meets the diagnostic criteria for type 2 diabetes in the China Type 2 Diabetes Prevention and Treatment Guidelines (2020 Edition);

⁃ Aged between 20 and 79 years old, without other severe underlying diseases; ③ Possesses full cognitive and literacy abilities; ④ Volunteers to participate in this study and are willing to sign an informed consent form.

Locations
Other Locations
China
The first hosptial of lanzhou university
RECRUITING
Lanzhou
Shanghai general hosptial
RECRUITING
Shanghai
The forth people's hosptial of shenyang
RECRUITING
Shenyang
Contact Information
Primary
Liping Gu Liping Gu
guliping1980@126.com
86-13564720656
Time Frame
Start Date: 2025-02-01
Estimated Completion Date: 2028-07-31
Participants
Target number of participants: 2920
Treatments
DR High-Risk Population Cohort
An annual follow - up fundus examination is conducted. Metabolic differences are analyzed between the population with progressed diabetic retinopathy (DR) and those without progression. A predictive model for early warning of DR in type 2 diabetes is constructed to forecast the onset of DR one year later.
Diabetic Retinopathy Early-Stage Population Cohort
Seeking specific metabolites that can reflect diabetic retinopathy and its severity in early - onset and late - onset type 2 diabetes mellitus (T2DM).
Moderate-Stage Diabetic Retinopathy (DR) Population Cohort
Exploring a multidisciplinary model of chronic disease management for patients in the middle stage of diabetic retinopathy (DR), with both the endocrinology department and the ophthalmology department jointly developing standardized standard operating procedures for systemic and ocular examinations of metabolic diseases.
Advanced-Stage Diabetic Retinopathy (DR) Population Cohort
The establishment of an integrated ward for diabetic eye diseases. For patients with severe diabetic eye diseases who urgently need ophthalmic surgery in the short term but have poor blood glucose control, the ophthalmology and endocrinology departments jointly manage and treat the patients. Endocrinologists adjust the blood glucose - lowering treatment plan. After the blood glucose stabilizes, ophthalmic surgery is performed. Continuous glucose monitoring is used to closely observe blood glucose fluctuations during the hospital stay, including intraoperative blood glucose. After the surgery, both ophthalmologists and endocrinologists jointly follow up with the patients.
Sponsors
Leads: Yufan Wang

This content was sourced from clinicaltrials.gov