Clinical Study Evaluating the Impact of Dapagliflozin on Erythropoiesis-Stimulating Agent Responsiveness in Anemic Patients With Chronic Kidney Disease

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor, primarily used in the management of type 2 diabetes mellitus. Emerging research suggests that SGLT2 inhibitors may offer additional benefits, including reducing the risk of cardiovascular events and renal complications. Post hoc analyses of previous clinical trials have shown that patients treated with SGLT2 inhibitors exhibited higher levels of hemoglobin and hematocrit compared to those in the control group. These findings suggest that dapagliflozin's ability to elevate hemoglobin levels could potentially be utilized for the treatment of anemia in patients with chronic kidney disease.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Adults aged ≥ 18 years with CKD stage III or IV.

• Patients with anemia of CKD and a hemoglobin level \< 11.5 g/dL

• Patients are receiving erythropoiesis-stimulating agent therapy.

Locations
Other Locations
Egypt
Urology and Nephrology Center
RECRUITING
Al Mansurah
Contact Information
Primary
Basma M. Sayed Ahmed, M.Sc.
basma_mohamed@mans.edu.eg
+201207753307
Time Frame
Start Date: 2025-04-01
Estimated Completion Date: 2025-10
Participants
Target number of participants: 80
Treatments
Experimental: Dapagliflozin + ESA group
patients will receive dapagliflozin 10 mg tablet once daily in addition to standard care therapy of erythropoiesis-stimulating agents (ESA)
Other: Control group
patients will receive standard care therapy of erythropoiesis-stimulating agents (ESA)
Related Therapeutic Areas
Sponsors
Leads: Mansoura University

This content was sourced from clinicaltrials.gov