The Association Between Cognitive Function and Diabetic Neuropathy in Individuals With Type 2 Diabetes
The goal of this observational study is to evaluate whether individuals with different types of diabetic neuropathy (peripheral and cardiovascular autonomic neuropathy) are at an increased risk of cognitive impairment and to investigate the potential reasons for this association. The primary research question is: Is diabetic peripheral and cariovascular autonomic neuropathy in type 2 diabetes associated with cognitive decline? To address this question, the study will include individuals with and without type 2 diabetes. All participants will undergo comprehensive neuropathy assessments, neuropsychological evaluations and blood biomarker analysis. In addition, some individuals will undergo structural and functional brain MRI.
⁃ For individuals with type 2 diabetes:
• Age \>= 65 years
• Type 2 Diabetes diagnosis (defined according to the criteria from World Health Organization) for more than 5 years
• BMI \<= 35
• Stable diabetes treatment for at least 8 weeks (adjustments of already prescribed insulin doses are accepted)
• Plasma hemoglobin ≥ 8.00 mmol/L (male) or ≥ 6.4 mmol/L (female)
• Speaks and understands Danish (required for the cognitive tests)
• Informed and written consent
⁃ For individuals without type 2 diabetes:
• Age ≥ 65 years
• Not diagnosed with T2D diagnosis (defined according to criteria from World Health Organization (WHO))
• Speaks and understands Danish (required for the cognitive tests)
• Informed and written consent