Impact of Cilostazol and Ginkgo Leaf Extract on Cognitive Function in Elderly Patients With Type 2 Diabetes

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 3
SUMMARY

This exploratory pilot study aims to evaluate the cognitive improvement effects of combination therapy with cilostazol (200 mg) and ginkgo biloba extract (160 mg) in elderly patients with type 2 diabetes mellitus. Both agents have demonstrated potential cognitive benefits through mechanisms such as enhanced cerebral blood flow, anti-inflammatory activity, and neuroprotection. Given the increased risk of cognitive decline and dementia in patients with type 2 diabetes, and the need for preventive strategies, this study will investigate whether the combination therapy can prevent or mitigate cognitive deterioration. Findings from this study may provide foundational data for the future development of therapeutic interventions targeting cognitive impairment in patients with diabetes.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 60
Healthy Volunteers: f
View:

• Patients diagnosed with type 2 diabetes mellitus

• Adults aged 60 years or older

• Patients with a Mini-Mental State Examination (MMSE) score between 24 and 28 within the past 3 months

Locations
Other Locations
Republic of Korea
Seoul National University Bundang Hospital
RECRUITING
Seongnam-si
Contact Information
Primary
Soo Lim Dr., MD PhD
limsoo@snu.ac.kr
+82-31-787-7035
Backup
Minji Sohn Dr, PhD
rainbowmjs@naver.com
Time Frame
Start Date: 2025-01-01
Estimated Completion Date: 2027-06-30
Participants
Target number of participants: 80
Treatments
Experimental: Cilostazol & Ginko Leaf Dried Ext.
Renexin CR tab (cilostazol 200mg / Ginko Leaf Dried Ext. 160mg)
Placebo_comparator: Placebo
Placebo
Related Therapeutic Areas
Sponsors
Collaborators: SK Chemicals Co., Ltd.
Leads: Seoul National University Bundang Hospital

This content was sourced from clinicaltrials.gov