Effects of High-Resistance Inspiratory Muscle Strength Training on Cardiorenal and Vascular Function in Youth and Young Adults With Type 2 Diabetes
Status: Recruiting
Location: See all (2) locations...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
High-resistance, short-duration inspiratory muscle strength training (IMST) is a novel lifestyle intervention involving 30 inhalations against a resistive load which requires only \ 5 min/day and is thus ideal for youth with T2D (Y-T2D). Investigators seek to 1: assess changes in casual and 24-hr SBP, endothelial function, and arterial stiffness after 3 months of IMST vs. sham training in Y-T2D, 2: Define changes in eGFR andalbuminuria after 3 months of IMST vs. sham in Y-T2D, 3: Interrogate mechanisms of IMST by translational assessments of NO bioavailability, endothelial NO synthase (eNOS) activation, and ROS/oxidative stress, and determine the role of circulating factors.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 14
Maximum Age: 40
Healthy Volunteers: f
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Locations
United States
Washington
Seattle Children's Hospital
RECRUITING
Seattle
University of Washington Medicine Diabetes Institute
NOT_YET_RECRUITING
Seattle
Contact Information
Primary
Kalie Tommerdahl, MD
ktomme@uw.edu
(206) 616-9015
Time Frame
Start Date: 2025-04-30
Estimated Completion Date: 2026-02-28
Participants
Target number of participants: 90
Treatments
Experimental: IMST
Using the POWERBreathe pressure threshold training device, participants will perform 30 inspiratory maneuvers (5 sets of 6, 1 min rest) 6 days/week for 3 months. This is an over the counter product that will be used according to its instructions. The IMST group will train at 75% maximal inspiratory pressure.
Sham_comparator: Sham/Placebo
Using the POWERBreathe pressure threshold training device, participants will perform 30 inspiratory maneuvers (5 sets of 6, 1 min rest) 6 days/week for 3 months. This is an over the counter product that will be used according to its instructions. The Sham group will train at 15% maximal inspiratory pressure.
Related Therapeutic Areas
Sponsors
Collaborators: University of Washington
Leads: Seattle Children's Hospital