Multi-day Effect of Noninvasive Brain Stimulation in Adults With Amblyopia

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this randomized controlled trial is to investigate the effectiveness of non-invasive brain stimulation in treating adults with amblyopia. The main questions it aims to answer are: 1. What are the effects of non-invasive brain stimulation on neuronal plasticity in the visual cortex of adults with amblyopia, and does it produce lasting changes? 2. Do cumulative sessions of non-invasive brain stimulation influence neural plasticity and higher-order visual functions in adults with amblyopia? The investigators hypothesize that non-invasive brain stimulation will show a positive cumulative effect after five (5) consecutive days of stimulation on visual perception and function in adults with amblyopia. Participants will be randomized into one of two treatment groups: 1. High-frequency transcranial random noise stimulation (hf-tRNS). 2. Sham stimulation. Researchers will compare baseline measurements of crowded visual acuity, contrast sensitivity, stereoacuity, phosphene thresholds, global motion perception, form pattern recognition and pattern-reversal visual evoked potentials (VEPs) to post-treatment measurements for each group.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Maximum Age: 55
Healthy Volunteers: t
View:

• Adults between 18 and 55 years of age

• Formal diagnosis of amblyopia in one or both eyes of any etiology

Locations
United States
Illinois
Midwestern University Eye Institute
RECRUITING
Downers Grove
Contact Information
Primary
Arijit Chakraborty, PhD
achakr@midwestern.edu
630-960-3172
Backup
Adrienne C Quan, OD
aquan@midwestern.edu
630-960-3183
Time Frame
Start Date: 2024-05-01
Estimated Completion Date: 2028-12-31
Participants
Target number of participants: 60
Treatments
Sham_comparator: Sham Stimulation
40-minute sessions of sham stimulation for 5 consecutive days.
Active_comparator: hf-tRNS Stimulation
40-minute sessions of hf-tRNS stimulation for 5 consecutive days.
Related Therapeutic Areas
Sponsors
Leads: Midwestern University

This content was sourced from clinicaltrials.gov