Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults
Status: Recruiting
Location: See location...
Intervention Type: Biological
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
Cellular and humoral immune responses before and after seasonal influenza vaccination will be assessed. Each year, up to 100 participants will be enrolled. To study age-specific differences in immune responses, participants with various years of birth will be enrolled. The investigators hypothesize that humans with different birth years will mount antibody and cellular responses of different specificities following seasonal influenza vaccination.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: t
View:
• Provision of signed and dated informed consent form
• Stated willingness to comply with all study procedures and availability for all study visits
• Aged 18 years and older
• In good health based on self-reported medical conditions via an online survey
Locations
United States
Pennsylvania
University of Pennsylvania
RECRUITING
Philadelphia
Contact Information
Primary
Scott Hensley, PhD
hensley@pennmedicine.upenn.edu
215-573-3756
Backup
Elizabeth Drapeau, PhD
elizabeth.troisi@pennmedicine.upenn.edu
215-573-3756
Time Frame
Start Date: 2021-10-07
Estimated Completion Date: 2028-03-31
Participants
Target number of participants: 700
Treatments
Experimental: Influenza vaccination
Adults will receive a seasonal, inactivated, quadrivalent influenza vaccine administered intramuscularly at a dose of 15 ug of HA per component, as approved by the FDA.
Related Therapeutic Areas
Sponsors
Collaborators: National Institute of Allergy and Infectious Diseases (NIAID), Stanford University, The Scripps Research Institute
Leads: University of Pennsylvania