The Effect of Exercise on Brain Energetics in Parkinson's Disease

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

There is increasing evidence that the usage and delivery of energy to the brain, known as brain energetics, is altered in people with Parkinson's disease (PD). This project will explore whether exercise has a positive impact on brain energetics using functional Magnetic Resonance Imaging (fMRI) and Positron Emission Tomography (PET) brain scanning in PD subjects. PD subjects will be scanned before and after a supervised exercise program to investigate the effect of exercise on brain energetics. In a separate study, the investigators will also scan healthy volunteers to compare brain energetics in the healthy brain with the brain energetics data in PD subjects acquired in this study.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 80
Healthy Volunteers: f
View:

• Idiopathic PD according to UK Brain Bank criteria (modified to permit inclusion of subjects with a family history)

• Mild to moderate Parkinsonism (Hoehn \& Yahr stages I-III)

• Currently exercise less than 120 minutes per week (PD non-exercisers)

Locations
Other Locations
Canada
Pacific Parkinson's Research Centre
RECRUITING
Vancouver
Contact Information
Primary
Jessamyn McKenzie
jess.mckenzie@ubc.ca
604 822 7764
Time Frame
Start Date: 2021-01-26
Estimated Completion Date: 2025-12-30
Participants
Target number of participants: 40
Treatments
Active_comparator: Immediate intervention start: active exercise
Immediately starts the six month intervention of active exercise following the baseline scan.
Placebo_comparator: Delayed intervention start: passive exercise
Starts the six month intervention of active exercise six months after the baseline scan. During the six month delay, participants in this arm undergo passive exercise.
Related Therapeutic Areas
Sponsors
Leads: Pacific Parkinson's Research Centre
Collaborators: Natural Sciences and Engineering Research Council, Canada

This content was sourced from clinicaltrials.gov