Prodromal Parkinsonian Features in GBA1 Mutation Carriers

Status: Recruiting
Location: See location...
Intervention Type: Diagnostic test
Study Type: Observational
SUMMARY

Objective of the trial. To define a sub-population which is at increased risk of developing Parkinson, beyond the fact of carrying Gaucher; in this sub-population the investigators shall conduct a comprehensive evaluation that includes a variety of non-invasive tests, whose purpose is to evaluate the state of the pre- Parkinson's disease signs, signs which can appear, even twenty years before the appearance of the disease, and also to compare them to a group of diagnosed Gaucher patients and a group of healthy people who are not carriers of Gaucher disease. A group of those carriers will be available for trial or for treatment, if there will be a medicine for the prevention of the development of Parkinson, obtainable.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Maximum Age: 75
Healthy Volunteers: t
View:

• Willing to participate

Locations
Other Locations
Israel
Michal Becker- Cohen
RECRUITING
Jerusalem
Contact Information
Primary
Ari Zimran, MD
azimran@gmail.com
+972-509149149
Backup
Michal Becker- Cohen, M.Sc.
michalbec@gmail.com
+972-504606310
Time Frame
Start Date: 2017-05-16
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 600
Treatments
Carriers of Gaucher disease
Family of patients with Gaucher disease, sequenced for the GBA1 gene.
Gaucher patients
Patients from the Gaucher clinic in Shaare Zedek Medical Center, Jerusalem, Israel
Healthy controls
Family members of Gaucher patients who are not carriers of Gaucher disease
Sponsors
Leads: Shaare Zedek Medical Center

This content was sourced from clinicaltrials.gov