The Effects of High-Frequency Repetitive Transcranial Magnetic Stimulation on Impulse Control Disorders in Parkinson's Disease Patients on Dopamine Replacement Therapy.

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study's objective is to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (dlPFC) of patients with Parkinson's Disease (PD) who experience impulse control disorders (ICDs) on impulse control symptoms and cognitive behaviors linked to ICDs: reinforcement learning and delay-discounting. This is a randomized sham-controlled cross-over trial. All patients will undergo a session of active rTMS and a session of sham rTMS, with the order of sessions randomized across participants. Following recruitment and eligibility screening, the eligible participants will undergo two sessions of rTMS (active and sham), immediately followed by neurocognitive tasks and questionnaires, no more than 1-2 weeks apart. Each session will have a duration of approximately 1-1.5 hours.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Clinician-confirmed diagnosis of PD

• Ability to provide informed consent, written and verbal

• Clinician-diagnosed impulse control disorder or impulse control behaviors including punding/hobbyism and dopamine dysregulation syndrome

• A Beck Depression Inventory (BDI) (Beck et al., 1961) score of 14 or lower

• A Montreal Cognitive Assessment (MoCA) (Nasreddine et al., 2005) score of 20 or higher

• On dopamine-replacement therapy

Locations
United States
West Virginia
West Virginia University Hospitals
RECRUITING
Morgantown
Contact Information
Primary
Mariya V Cherkasova, PhD
mariya.cherkasova@mail.wvu.edu
2403673068
Time Frame
Start Date: 2024-05-01
Estimated Completion Date: 2026-05
Participants
Target number of participants: 20
Treatments
Active_comparator: rTMS Active
the participant will receive a type of TMS called repetitive TMS (rTMS) wherein the magnetic pulses delivered will be close together in a rapid sequence over the dlPFC. Participants receive excitatory rTMS with a stimulation frequency of 20 Hz between 100-120% of their resting motor threshold.
Sham_comparator: rTMS Sham
Sham rTMS will be the same as real rTMS, except a special sham coil will be used, which produces the same sensation on the scalp of the patients as the real coil but delivers no magnetic stimulation to the brain.
Related Therapeutic Areas
Sponsors
Leads: West Virginia University

This content was sourced from clinicaltrials.gov