Can High-intensity Exercise be Used to Treat Fatigue in Parkinson´s Disease?

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The primary goal of this study is to test whether 12 weeks of high-intensity aerobic exercise can treat fatigue in Parkinsons disease (PD). The study will be a randomized multi-site controlled trial with follow up. Clinically fatigued persons with PD will be allocated to either 12 weeks of high-intensity aerobic exercise or to a waitlist control group receiving high-intensity resistance exercise after 24 weeks of habitual lifestyle (control period). It is hypothesized that persons with PD receiving 12 weeks of high-intensity aerobic exercise will show superior effects on perceived fatigue (i.e., clinical relevant reductions) when compared to the PD control group (primary hypothesis), and that these effects are sustained after 12-weeks of follow up (secondary hypothesis).

Eligibility
Participation Requirements
Sex: All
Minimum Age: 40
Healthy Volunteers: f
View:

• Minimum 40 years

• Diagnosed with Idiopathic Parkinsons disease

• Stable in medical treatment for six month

• Able to transport themselves to and from exercise and testing sessions (with or without assistance)

• H\&Y score of three or lower

Locations
Other Locations
Denmark
Exercise Biology, Dep. of Public Health, Aarhus University
RECRUITING
Aarhus
Contact Information
Primary
Cecilie Thrue, PhD student
ceth@ph.au.dk
+4520768102
Backup
Ulrik Dalgas, Professor
dalgas@ph.au.dk
Time Frame
Start Date: 2024-04-24
Estimated Completion Date: 2026-12-01
Participants
Target number of participants: 94
Treatments
Experimental: Aerobic exercise group
Participants must be clinically fatigued when enrolled and furthermore meet additional inclusion criteria.
Experimental: Waitlist control group/resistance exercise group
Participants must be clinically fatigued when enrolled and furthermore meet additional inclusion criteria.
Related Therapeutic Areas
Sponsors
Leads: University of Aarhus

This content was sourced from clinicaltrials.gov