Exploring the Effects of Exercise on Memory and Cognition in Parkinson´s Disease

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The study aims to assess the effects of cardiovascular (aerobic) training on memory formation and cognitive function in people with Parkinson's disease. Participants will be randomly allocated to one of two groups either performing cardiovascular training (experimental group) or stretching (control group) for twelve weeks, three times a week. The primary aim is to examine whether moderate-intense cardiovascular training (MICT) improves procedural memory formation (primary outcome) compared to stretching. Secondary outcomes include episodic memory formation, cognitive function, cardiorespiratory fitness, sleep quality, and brain-derived neurotrophic factor (BDNF) blood concentration levels.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 80
Healthy Volunteers: f
View:

• Diagnosed Parkinson's disease

• Disease stage ≤3 on the Hoehn \& Yahr scale

• Age ranging from 50 - 80 years

• Naive to the memory tasks (primary outcomes)

• Ability to stand and walk at least 10 meters independently

Locations
Other Locations
Germany
Heidelberg University
RECRUITING
Heidelberg
Contact Information
Primary
Simon Steib, Prof. Dr.
simon.steib@issw.uni-heidelberg.de
+49 6221/544643
Backup
Philipp Wanner, Dr.
philipp.wanner@issw.uni-heidelberg.de
+49 6221/544633
Time Frame
Start Date: 2024-02-27
Estimated Completion Date: 2027-07
Participants
Target number of participants: 60
Treatments
Experimental: cardiovascular training
The experimental group will perform a cardiovascular training three times a week over 12 weeks.
Active_comparator: stretching
The active control group will perform a stretching training three times a week over 12 weeks.
Related Therapeutic Areas
Sponsors
Collaborators: German Foundation for Neurology, Universitätsmedizin Mannheim, SRH Kurpfalzkrankenhaus Heidelberg, University Hospital Heidelberg
Leads: Heidelberg University

This content was sourced from clinicaltrials.gov