Association of Transcranial Alternating Current Stimulation with Digital Cognitive Training for Cognitive Remediation in Older Adults

Status: Recruiting
Location: See location...
Intervention Type: Device
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

BACKGROUND Cognitive decline in older adults, especially those who develop Mild Cognitive Impairment and Alzheimer's Disease, currently has limited options of pharmacological treatments, with modest efficacy. Digital Cognitive Training (DCT) and Transcranial Alternating Current Stimulation (tACS) are two promising tools for cognitive remediation in this population. In this exploratory study, we investigate feasibility, tolerability and preliminary effects of the association of both interventions in older adults with cognitive complaints. METHODS Older adults with cognitive complaints are being enrolled for this study, which comprises 5 daily sessions of 30 minutes of DCT using the BrainHQ platform while simultaneously receiving theta tACS (6Hz, 1.6mA) targeting the Left Dorsolateral Prefrontal Cortex.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Healthy Volunteers: t
View:

• Healthy subjects over 50 years old, with cognitive complaints

Locations
Other Locations
Brazil
Clínica da Memória - IPUB / UFRJ
RECRUITING
Rio De Janeiro
Contact Information
Primary
Rogerio Panizzutti, Professor
rogerio.panizzutti@ipub.ufrj.br
+55:21-3938-5588
Backup
Brunno Costa, PhD student
fc_brunno@hotmail.com
+55 31996773008
Time Frame
Start Date: 2024-12-02
Estimated Completion Date: 2027-03-01
Participants
Target number of participants: 40
Treatments
Experimental: tACS+DCT
5 daily sessions of 30 minutes of DCT using the BrainHQ platform while simultaneously receiving theta tACS (6Hz, 1.6mA) targeting the Left Dorsolateral Prefrontal Cortex.
Sham_comparator: SHAM+DCT
5 daily sessions of 30 minutes of DCT using the BrainHQ platform while simultaneously receiving stimulation with the device in SHAM mode (with Ramp Up, no current during the session period and Ramp down) targeting the Left Dorsolateral Prefrontal Cortex.
Sponsors
Collaborators: Alzheimer's Association, Conselho Nacional de Desenvolvimento Científico e Tecnológico, Rio de Janeiro State Research Supporting Foundation (FAPERJ)
Leads: Universidade Federal do Rio de Janeiro

This content was sourced from clinicaltrials.gov