TURN-IT FOG: A Novel Intervention to Improve Turning in People With PD and Freezing of Gait

Status: Recruiting
Location: See all (3) locations...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goals of this clinical trial are to 1) learn how two different rehabilitation interventions for PD can reduce Freezing of Gait (FOG) in people with Parkinson's disease, as assessed by patients, clinicians, and wearable sensors, and 2) to explore whether two different rehabilitation intervention can reduce FOG and improve daily life mobility in people with FOG sufficiently to justify a clinical trial. Participants will: * Be randomly assigned to one of two intervention groups (turning-focused agility exercise or strength-based exercise) * Have one-on-one training sessions three times per week for 6 weeks * Perform in-lab assessments before beginning and after completing the study intervention * Use wearable mobility sensors during daily life to measure their walking and balance

Eligibility
Participation Requirements
Sex: All
Minimum Age: 50
Maximum Age: 80
Healthy Volunteers: f
View:

• diagnosis of idiopathic PD from movement disorders neurologist with the United Kingdom Brain Bank criteria of bradykinesia with one or more of the following - rest tremor, rigidity, and balance problems not from visual, vestibular, cerebellar or proprioceptive conditions

• reporting FOG in the New Freezing of Gait questionnaire (N-FOGQ)

• Hoehn \& Yahr stages II-IV

• ages 50-80 years old

• cognitive ability sufficient to participate in testing procedures and exercise classes

• be willing and able to participate in exercise intervention 3x/week for 6 weeks

Locations
United States
Arizona
Arizona State University
RECRUITING
Tempe
Oregon
Oregon Health and Science University
RECRUITING
Portland
Other Locations
Brazil
University of São Paulo, Bauru Campus
RECRUITING
Bauru
Contact Information
Primary
Graham R Harker, MPH
harkerg@ohsu.edu
(503) 418-2601
Time Frame
Start Date: 2025-06-02
Estimated Completion Date: 2027-06-30
Participants
Target number of participants: 60
Treatments
Experimental: Dynamic balance exercise intervention group
Six weeks of exercise intervention to improve gait disturbances.~Specific participant procedures in experimental and active control interventions are simplified to preserve study blinding.
Active_comparator: Strength training exercise intervention group
Six weeks of exercise intervention to improve gait disturbances.~Specific participant procedures in experimental and active control interventions are simplified to preserve study blinding.
Related Therapeutic Areas
Sponsors
Collaborators: Michael J. Fox Foundation for Parkinson's Research
Leads: Oregon Health and Science University

This content was sourced from clinicaltrials.gov

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