Interest of Follicular Helper Lymphocytes / Regulatory Follicular Helper Lymphocytes Ratio to Characterize and Predict Poor Prognosis Forms in IgA Nephropathy: an Exploratory Proof-of-concept Study
Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
This study aims to investigate the relevance of the Tfh/Tfr (Follicular helper T cells/ Follicular regulatory T cells) ratio in patients with IgA nephropathy: * To identify a differential expression of the Tfh/Tfr ratio in patients considered stable or progressive * To predict, at diagnosis, the clinical evolution of the disease (progressive or stable form) in the first year.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• IgA nephropathy histologically proven on renal biopsy according to KDIGO criteria, with 8 permeable glomeruli (patients diagnosed from 2009 with a minimum follow-up for their nephropathy of 5 years (arm 1) or patients diagnosed during the study (arm 2))
⁃ Control patients: Lupus or ANCA-associated vasculitis or polycystic kidney disease (arm 3)
Locations
Other Locations
France
Centre Hospitalier Universitaire de Besançon
RECRUITING
Besançon
Contact Information
Primary
Charline Vauchy, PhD.
cvauchy@chu-besancon.fr
0381218875
Time Frame
Start Date: 2023-05-23
Estimated Completion Date: 2026-05
Participants
Target number of participants: 75
Treatments
Other: IgA nephropathy in follow-up (arm 1)
Diagnosis of IgA nephropathy from 2009, with a minimum follow-up for nephropathy of 5 years
Other: Newly diagnosed IgA nephropathy (arm 2)
Diagnosis of IgA nephropathy during the study period
Other: CD163s control (arm 3)
Diagnosis of Lupus or ANCA-associated vasculitis or polycystic kidney disease
Related Therapeutic Areas
Sponsors
Leads: Centre Hospitalier Universitaire de Besancon