• Subject has provided written informed consent prior to initiation of study-specified procedures.

• Subject is 18 years of age or older.

• Eastern Cooperative Oncology Group performance status 0, 1 or 2.

• Subject has a single lesion that is histologically confirmed as BCC. The externally visible component of the lesions should be at least 1 cm in one dimension to facilitate accurate and reproducible measurement, to 5 cm at longest diameter, that in the opinion of the investigator:

• A. is considered not a good candidate for surgery or has recurred after definitive surgical treatment and curative surgical resection is unlikely. OR

• B. subject has a medical contraindication to surgery where acceptable medical contraindications to surgery include:

⁃ Anticipated substantial morbidity and/or deformity from surgery (e.g., removal of all or part of a vital facial structure, such as nose, ear, eyelid, eye; or requirement for limb amputation).

⁃ Medical conditions predisposing to poor surgical outcome (e.g., diabetes with history of poor wound healing).

⁃ Other conditions considered to be medically contraindicating must be discussed with the Medical Monitor before enrolling the subject.

• A copy of the surgical consultation note must be provided. laBCC with prior history of or ongoing HPPI treatment are eligible under the following conditions:

⁃ Achieved objective response with disease progression \>3 months after treatment discontinuation.

⁃ Achieve best response of PR with persistent disease that continues to meet study inclusion criteria and has been off treatment for at least 3 months.

• Note: where the subject has \>1 lesion, one lesion may be selected for treatment at the discretion of the investigator.

• Radiotherapy is contraindicated or inappropriate in the opinion of the investigator, for example, hypersensitivity to radiation due to genetic syndrome such as Gorlin syndrome, limitations because of location of tumor, or anticipated significant morbidity, loss of function, or unacceptable cosmetic outcomes. Patients with Basal Cell Nevus Syndrome (Gorlin syndrome) may enroll in this study but must meet the criteria for locally advanced or listed above.

• Subject is able and willing to comply with all study requirements including biopsies at baseline and during the study. Biopsy 3-4 mm preferred, biopsies must be \<25% of the area the tumor. Screening biopsies performed 1-12 weeks before Day 1.

• Subject has adequate hematopoietic capacity, as defined by the following:

‣ Neutrophil count \>1,500/mm3

⁃ Hemoglobin \>9 g/dL

⁃ Platelet count \>100,000/ mm3

⁃ Prothrombin international normalized ratio \<1.5

• Subject has adequate hepatic function, as defined by the following:

‣ Total bilirubin \<1.5 × the upper limit of normal (ULN) or within 3 × the ULN for patients with Gilbert disease

⁃ Aspartate aminotransferase, alanine aminotransferase or alkaline phosphate \<2 × the ULN

• Adequate renal function, as defined by the following:

‣ Creatinine \<1.5 x ULN

⁃ For female subjects of childbearing potential\*, agreement to use two acceptable methods of contraception (including one barrier method), during the study and for at least (per United States Prescribing Information \[USPI\]) 24 months after discontinuation of vismodegib.

⁃ For male subjects with female partners of childbearing potential\*, agreement to use a latex condom, and to advise their female partner to use an additional method of contraception during the study and for at least (per USPI) 24 months after discontinuation of vismodegib.

⁃ Subjects agree not to donate blood or blood products during the study and for at least (per USPI) 24 months after discontinuation of vismodegib; male subjects agree not to donate sperm during the study and for at least 2 months after discontinuation of vismodegib.

∙ Childbearing potential is defined as any female who has experienced menarche and who has not undergone surgical sterilization (hysterectomy or bilateral oophorectomy) and is not postmenopausal. Menopause is defined as 12 months of amenorrhea in the absence of other biological causes. In addition, females under the age of 55 years must have a documented serum follicle stimulating hormone level \>40 mIU/mL to confirm menopause.