Does Itopride Improve Semaglutide Induced Gastroparesis Ultrasound Before Anesthesia? Randomized Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY
Semaglutide delays gastric emptying and increases the risk of aspiration with anesthesia; So, the addition of prokinetics as Itopride, could enhance gastric emptying and hasten surgery. The investigator will evaluate the effect of Itopride on Semaglutide-induced gastroparesis and residual gastric contents after 8 hours of fasting by gastric ultrasound before anesthesia.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 40
Maximum Age: 60
Healthy Volunteers: f
View:
• American Society of Anesthesiologists grade I- III.
• Age: 40-60 years.
• BMI: 20-30 kg/m2.
• Diabetic patients on semaglutide (0.5-1mg) SC weekly.
• Undergoing elective hysterectomy.
Locations
Other Locations
Egypt
faculty of medicine, Ain Shams University
RECRUITING
Cairo
Contact Information
Primary
tamer Samir abdelaziz, MD
drtasamir@hotmail.com
+201154601505
Time Frame
Start Date: 2025-12
Estimated Completion Date: 2026-04
Participants
Target number of participants: 60
Treatments
Active_comparator: Itopride HCL
Daily oral 50mg Itopride tablet TID, 1 hour before meals for 7 days
Placebo_comparator: Placebo
Daily placebo tablet TID, 1 hour before meals for 7 days
Related Therapeutic Areas
Sponsors
Leads: Ain Shams University