• patients developing breast cancer as confirmed by X-ray examination, cancer tissue negative for estrogen receptor, progesterone receptor and HER2, and tumor stage II-III;

• estimated survival \> 3 months;

• presence of clinically measurable lesions;

• Karnofsky functional status score ≥ 70;

• normal routine blood test results, normal liver and kidney function, and near normal electrocardiographic manifestations;

• age at 18-70 years.