The PhOCus Trial: Implementation of Pharmacogenomic Testing in Oncology Care

Status: Recruiting
Location: See location...
Intervention Type: Other
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

Doctors leading this study hope to find out if giving study participants' genetic information to cancer care providers will help personalize chemotherapy dosing decisions and decrease common chemotherapy side effects. Doctors leading the study will collect genetic information from study participants using pharmacogenomics/genotyping. Pharmacogenomics is the study of how the differences in our genes can affect our unique response to medications. This is a randomized study, which means that participants in this study will be randomly assigned (as if by flip of a coin) to one of two different groups: a pharmacogenomics group or control group.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
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• Individuals of all genders, races and ethnic groups are eligible for this trial. There is no bias towards race, sex, or gender in the clinical trial outlined.

Locations
United States
Illinois
University of Chicago Medical Center
RECRUITING
Chicago
Contact Information
Primary
Peter H. O'Donnell, MD
podonnel@medicine.bsd.uchicago.edu
773-834-0936
Time Frame
Start Date: 2022-02-07
Estimated Completion Date: 2028-03-31
Participants
Target number of participants: 860
Treatments
No_intervention: Control Group
Participants assigned to the control group will receive standard chemotherapy without their doctors receiving any genetic information based on the participants' pharmacogenetic results. DNA (Deoxyribonucleic acid) samples for participants in this group will be stored and tested for genotyping six months later after treatment (or earlier if the participant experiences side effects).
Experimental: Pharmacogenomics Group
Participants enrolled in the pharmacogenomics group will give a DNA (deoxyribonucleic acid) sample for immediate pharmacogenomic genotyping. Once the genotyping results are in, cancer doctors caring for each participant will have immediate access to clinical decision support based on the participant's genetic results and can make dosing decisions/changes to the participant's chemotherapy prescription.
Authors
Peter O'Donnell
Sponsors
Leads: University of Chicago

This content was sourced from clinicaltrials.gov