A Phase II/III Study of SPH4336 in Combination With Endocrine Therapy in the Treatment of HR-positive, HER2-negative Locally Advanced or Metastatic Breast Cancer That Progressed on CDK4/6 Inhibitor Combined With Endocrine Therapy
Status: Recruiting
Location: See all (22) locations...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 2/Phase 3
SUMMARY
This study evaluated the safety and efficacy of SPH4336 in combination with endocrine therapy in the treatment of locally advanced or metastatic breast cancer that progressed on CDK4/6 inhibitor combined with endocrine therapy.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 75
Healthy Volunteers: f
View:
• Patients who voluntarily participate in this study, completely understand this study, and voluntarily sign the informed consent form (ICF).
• ECOG (Eastern Cooperative Oncology Group) performance status score of 0 or 1.
• Life expectancy ≥ 3 months.
• Patients with locally advanced or metastatic breast cancer who are unable to receive radical surgeries/other local therapies.
• At least one measurable lesion.
• Laboratory test results meet the relevant requirements for organ function.
• Subjects who agree to take effective contraceptive measures.
Locations
Other Locations
China
Anyang Cancer Hospital
RECRUITING
Anyang
Peking Union Medical College Hospital
RECRUITING
Beijing
The First Affiliated Hospital of Bengbu Medical College
RECRUITING
Bengbu
Jilin Cancer Hospital
RECRUITING
Changchun
Fujian Cancer Hospital
RECRUITING
Fuzhou
Affiliated Cancer Hospital, Sun Yat-sen University
RECRUITING
Guangzhou
Zhejiang cancer Hospital
RECRUITING
Hangzhou
Harbin Medical University cancer Hospital
RECRUITING
Harbin
First Affiliated Hospital of Kunming Medical University
RECRUITING
Kunming
Yunnan Cancer Hospital
RECRUITING
Kunming
Liuzhou people's Hospital
RECRUITING
Liuzhou
The First Affiliated Hospital of Henan University of Science and Technology
RECRUITING
Luoyang
Jiangsu Cancer Hospital
RECRUITING
Nanjing
Jiangsu Province Hospital
RECRUITING
Nanjing
The second people's hospital of neijiang
RECRUITING
Neijiang
The First Hospital of China Medical University
RECRUITING
Shenyang
Shenzhen Hospital of University of Hong Kong
RECRUITING
Shenzhen
The Fourth Hospital of Hebei Medical University
RECRUITING
Shijiazhuang
Tianjin Medical University Cancer Institute & Hospital
RECRUITING
Tianjin
Xiangyang Cancer Hospital
RECRUITING
Wuhan
The First Affiliated Hospital of Xi'an Jiao Tong University