A Prospective, Non-interventional Study (NIS) With Trastuzumab Deruxtecan For Patients With HER2-low Expressing Unresectable and/or Metastatic Breast Cancer Accompanied By a Disease Registry of Patients Treated With Conventional Chemotherapy (DESTINY Breast Respond HER2-low Europe)
Status: Recruiting
Location: See all (198) locations...
Intervention Type: Drug
Study Type: Observational
SUMMARY
Trastuzumab deruxtecan (T-DXd) as monotherapy is indicated for the treatment of adult patients with unresectable or metastatic HER2-low breast cancer who have received prior chemotherapy in the metastatic setting or developed disease recurrence during or within 6 months of completing adjuvant chemotherapy.
Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:
• Adult patient (age ≥ 18 years) with histological or cytological confirmed diagnosis of unresectable and/or mBC
• Documented HER2-low status (IHC1+, IHC2+/ISH-)
• Patients who have received prior chemotherapy in the metastatic setting or patients who have developed disease recurrence during or within 6 months of completing adjuvant chemotherapy
• Decision to newly initiate therapy of T-DXd or conventional chemotherapy according to the physicians choice per SmPC
• Written and signed Informed Consent to participate in the study
Locations
Other Locations
Austria
Medizinische Universität Graz
RECRUITING
Graz
Medizinische Universität Graz
TERMINATED
Graz
Medizinische Universität Innsbruck
RECRUITING
Innsbruck
Klinikum Klagenfurt am Wörthersee
RECRUITING
Klagenfurt
LKH Hochsteiermark-Leoben
WITHDRAWN
Leoben
Ordensklinikum Linz GmbH Barmherzige Schwestern
RECRUITING
Linz
Interne II, LKH Feldkirch
RECRUITING
Rankweil
KH der Barmherzigen Brüder Salzburg
RECRUITING
Salzburg
Uniklinikum Salzburg
RECRUITING
Salzburg
Krankenhaus Hietzing
RECRUITING
Vienna
Medical University of Vienna
RECRUITING
Vienna
Medizinische Universität Wien
TERMINATED
Vienna
Salzkammergut Klinikum Vöcklabruck
RECRUITING
Vöcklabruck
Klinikum Wels-Grieskirchen GmbH
RECRUITING
Wels
Landesklinikum Wiener Neustadt
RECRUITING
Wiener Neustadt
Belgium
ASZ Aalst
RECRUITING
Aalst
Chirec Delta Hospital
RECRUITING
Auderghem
Imeldaziekenhuis Bonheiden
RECRUITING
Bonheiden
AZ Klina
RECRUITING
Brasschaat
AZ Sint-Jan Brugge av
RECRUITING
Bruges
CHU Brugmann
RECRUITING
Brussels
Cliniques universitaires Saint-Luc
RECRUITING
Brussels
Chu Helora- Hôpital de La Louvière- site Jolimont
RECRUITING
Haine-saint-paul
Jessa Ziekenhuis
NOT_YET_RECRUITING
Hasselt
CHU Tivoli
RECRUITING
La Louvière
CHC MontLegia
RECRUITING
Liège
Hôpital de la Citadelle
RECRUITING
Liège
CHU UCL Namur/Site Sainte Elisabeth
RECRUITING
Namur
Clinique Saint Pierre Ottignies
RECRUITING
Ottignies
VITAZ
RECRUITING
Sint-niklaas
CHR Verviers East Belgium
RECRUITING
Verviers
Denmark
Aalborg Universitetshospital, Syd
TERMINATED
Aalborg
Aarhus University Hospital
RECRUITING
Aarhus N
Herlev Hospital
RECRUITING
Herlev
Onkologisk og Palliativ afdeling, Nordsjællands Hospital
RECRUITING
Hillerød
Naestved Hospital
RECRUITING
Næstved
Sygehus Sønderjylland, Sønderborg
TERMINATED
Sønderborg
France
CHU Amiens Picardie
RECRUITING
Amiens
Clinique de l'Europe
RECRUITING
Amiens
Hôpital Privé d'Antony
NOT_YET_RECRUITING
Antony
Hôpital Privé les Bonnettes
NOT_YET_RECRUITING
Arras
Institut du Cancer Avignon Provence
RECRUITING
Avignon
CH Cote Basque
RECRUITING
Bayonne
Clinique Belharra
RECRUITING
Bayonne
Chu Jean Minjoz Besancon
RECRUITING
Besançon
Clinique Tivoli-Ducos
RECRUITING
Bordeaux
Centre hospitalier Fleyriat
RECRUITING
Bourg-en-bresse
Centre Francois Baclesse
RECRUITING
Caen
Centre Hospitalier William Morey
RECRUITING
Chalon-sur-saône
CH Metropole Savoie
RECRUITING
Chambéry
Pole Sante Leonard De Vinci
RECRUITING
Chambray-lès-tours
CH Cholet
RECRUITING
Cholet
Centre Jean Perrin
RECRUITING
Clermont-ferrand
Polyclinique St Côme
NOT_YET_RECRUITING
Compiègne
Hôpital Henri Mondor
RECRUITING
Créteil
Centre Léonard de Vinci
RECRUITING
Dechy
Centre Georges Francois Leclerc
RECRUITING
Dijon
CHU Martinique
NOT_YET_RECRUITING
Fort De France Cedex
CHI Frejus Saint Raphael
RECRUITING
Fréjus
Groupe Hospitalier Mutualiste (GHM) de Grenoble - Institut Daniel Hollard (IDH)
RECRUITING
Grenoble
Polyclinique De Blois
RECRUITING
La Chaussée-saint-victor
La Tronche - CHU Grenoble
RECRUITING
La Tronche
Centre de cancerologie de la Sarthe
NOT_YET_RECRUITING
Le Mans
Centre Hospitalier Emile Roux
RECRUITING
Le Puy-en-velay
Hôpital Franco-Britannique Cognac Jay
NOT_YET_RECRUITING
Levallois-perret
Centre Oscar Lambret
NOT_YET_RECRUITING
Lille
CHU Lille
RECRUITING
Lille
Hôpital Prive Le Bois
RECRUITING
Lille
CHU de Limoges
NOT_YET_RECRUITING
Limoges
Hôpital Jean Mermoz
NOT_YET_RECRUITING
Lyon
Hospices Civils De Lyon
RECRUITING
Lyon
Hôpital-Clinique Claude Bernard
NOT_YET_RECRUITING
Metz
GH Havre
RECRUITING
Montivilliers
Clinique Clementville
RECRUITING
Montpellier
Groupe Hospitalier privé Ambroise Pare Hartmann
RECRUITING
Neuilly-sur-seine
Hopital Americain de Paris
RECRUITING
Neuilly-sur-seine
Centre Antoine Lacassagne
RECRUITING
Nice
Centre Médical ONCOGARD
RECRUITING
Nîmes
Centre Hospitalier de Niort
RECRUITING
Niort
Groupement Hospitalier Diaconesses Croix Saint Simon
RECRUITING
Paris
Hopital Europeen Georges Pompidou
RECRUITING
Paris
Hôpital Saint Joseph
NOT_YET_RECRUITING
Paris
Institut Curie
RECRUITING
Paris
Centre Hospitalier de Pau
RECRUITING
Pau
CHU Poitiers
RECRUITING
Poitiers
Institut Godinot
RECRUITING
Reims
Polyclinique Courlancy
RECRUITING
Reims
Centre Eugene Marquis
RECRUITING
Rennes
Clinique Mathilde
RECRUITING
Rouen
Clinique Saint Hilaire
WITHDRAWN
Rouen
Saint Cloud -Rene Huguenin Institut Curie
NOT_YET_RECRUITING
Saint-cloud
CHU Réunion Site Sud
RECRUITING
Saint-paul
Institut De Cancerologie Paris Nord
NOT_YET_RECRUITING
Sarcelles
Centre Hospitalier de Sens
RECRUITING
Sens Cédex
Hôpital Foch
RECRUITING
Suresnes
CHR Metz Thionville
RECRUITING
Thionville
HIA Sainte-Anne
RECRUITING
Toulon
Centre Hospitalier de Troyes
WITHDRAWN
Troyes
Hopital Prive Drome Ardeche
RECRUITING
Valence
Nouvelle Clinique Des Dentellières
RECRUITING
Valenciennes
Institut De Cancerologie De Lorraine
WITHDRAWN
Vandœuvre-lès-nancy
Centre d'oncologie Saint-Yves
RECRUITING
Vannes
Médipôle Hôpital Mutualiste
NOT_YET_RECRUITING
Villeurbanne
Italy
Azienda Ospedaliera di Alessandria
RECRUITING
Alessandria
Ospedale SS Annunziata
RECRUITING
Chieti
Ospedale Citta' di Castello USL Umbria 1
RECRUITING
Città Di Castello
Ospedale San Giuseppe - Azienda USL Toscana Centro
RECRUITING
Empoli
ASL Lecce - Ospedale Vito Fazzi
RECRUITING
Lecce
ASST Lecco - PO Alessandro Manzoni
RECRUITING
Lecco
AULSS 9 Scaligera - Ospedale Mater Salutis
RECRUITING
Legnago
ASST Ovest Milanese - Ospedale di Legnano
RECRUITING
Legnano
Ospedale Generale Provinciale di Macerata
RECRUITING
Macerata
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori - IRST IRCCS
RECRUITING
Meldola
AOU di Modena
RECRUITING
Modena
Fondazione IRCCS San Gerardo dei Tintori
RECRUITING
Monza
AOU Federico II
RECRUITING
Napoli
AOU Maggiore della Carità di Novara
RECRUITING
Novara
IOV - Istituto Oncologico Veneto - IRCCS
RECRUITING
Padua
ARNAS Ospedale Civico e Benfratelli
RECRUITING
Palermo
La Maddalena S.p.A.
RECRUITING
Palermo
Fondazione IRCCS Policlinico San Matteo
RECRUITING
Pavia
AOU Pisana - Stabilimento Santa Chiara
RECRUITING
Pisa
AO Regionale San Carlo
RECRUITING
Potenza
GOM BMM - Presidio Ospedaliero Morelli
RECRUITING
Reggio Calabria
Azienda USL IRCCS di Reggio Emilia
RECRUITING
Reggio Emilia
AO San Giovanni Addolorata
RECRUITING
Roma
ASL RM 2 Ospedale Pertini
RECRUITING
Roma
AOU San Giovanni di Dio e Ruggi d'Aragona
RECRUITING
Salerno
IRCCS Ospedale Casa Sollievo della Sofferenza
RECRUITING
San Giovanni Rotondo
AOU Sassari - Ospedale Civile SS. Annunziata
RECRUITING
Sassari
Ospedale San Vincenzo
RECRUITING
Taormina
AO Ordine Mauriziano
RECRUITING
Torino
AOU Città della Salute e della Scienza di Torino - Ospedale Molinette
RECRUITING
Torino
AULSS n. 2 Marca trevigiana - Ospedale Cà Foncello
RECRUITING
Treviso
ASUFC Udine - Santa Maria della Misericordia
RECRUITING
Udine
ASST Sette Laghi Ospedale di Circolo e Fondazione Macchi
RECRUITING
Varese
Norway
Nordlandssjukhuset Bodø
RECRUITING
Bodø
Drammen Sykehus
RECRUITING
Drammen
Sørlandet sykehus / Kristiansand Hospital
RECRUITING
Kristiansand
Sykehuset Telemark
RECRUITING
Skien
Universitetssjukhuset Nord-Norge
RECRUITING
Tromsø
Spain
Hospital Clinico Universitario de Albacete
RECRUITING
Albacete
Hospital Universitario de La Ribera
RECRUITING
Alzira
Hospital Universitario de Cruces
RECRUITING
Barakaldo
Hospital de la Santa Creu i Sant Pau
NOT_YET_RECRUITING
Barcelona
Hospital Universitario de Basurto
RECRUITING
Bilbao
Hospital Universitario San Pedro de Alcántara
NOT_YET_RECRUITING
Cáceres
Hospital Universitario de Puerto Real
RECRUITING
Cadiz
Hospital Universitario Reina Sofia
NOT_YET_RECRUITING
Córdoba
Hospital General Universitario de Elche
NOT_YET_RECRUITING
Elche
Hospital de Galdakao
RECRUITING
Galdakao
Hospital Clinico Universitario de Granada (PTS)
RECRUITING
Granada
Hospital Universitario Médico-Quirúrgico de Jaén
RECRUITING
Jaén
Complejo Asistencial Universitario de León
RECRUITING
León
Hospital Universitario San Pedro de Logroño
WITHDRAWN
Logroño
Hospital Universitario Lucus Augusti
RECRUITING
Lugo
Hospital Clínico Universitario San Carlos
RECRUITING
Madrid
Hospital de Getafe
RECRUITING
Madrid
Hospital MD Anderson Cancer Center
RECRUITING
Madrid
Hospital Universitario 12 de Octubre
RECRUITING
Madrid
Hospital Universitario la Princesa
RECRUITING
Madrid
Hospital Universitario Ramón y Cajal
RECRUITING
Madrid
Hospital Virgen Arrixaca de Murcia
RECRUITING
Murcia
Hospital Universitario Central de Asturias
RECRUITING
Oviedo
Complejo Asistencial Universitario de Palencia
RECRUITING
Palencia
Hospital Son Llatzer
RECRUITING
Palma
Hospital Son Espases
RECRUITING
Palma De Mallorca
Hospital de Pontevedra
RECRUITING
Pontevedra
Hospital San Joan de Reus
RECRUITING
Reus
Hospital Universitari Parc Taulí
RECRUITING
Sabadell
Hospital Universitario de Canarias
RECRUITING
San Cristóbal De La Laguna
Hospital General de Catalunya
RECRUITING
Sant Cugat Del Vallès
Hospital Universitario Marqués de Valdecilla
RECRUITING
Santander
Hospital Universitario General de Valencia
RECRUITING
Valencia
Hospital Clínico de Valladolid
RECRUITING
Valladolid
Hospital Universitario Rio Hortega
RECRUITING
Valladolid
Complejo Hospitalario Universitario De Vigo
RECRUITING
Vigo Pontevedra
Sweden
Onkologikliniken Mälarsjukhuset
RECRUITING
Eskilstuna
Gävle Hospital
RECRUITING
Gävle
Ryhov County Hospital
RECRUITING
Jönköping
Department of Oncology, Örebro University Hospital
RECRUITING
Örebro
Bröstcentrum, Karolinska Universitetssjukhuset Solna
RECRUITING
Stockholm
Capio St Görans sjukhus
RECRUITING
Stockholm
Onkologkliniken Sundsvalls Sjukhus
WITHDRAWN
Sundsvall
Cancercentrum, Norrlands Universitetssjukhus
NOT_YET_RECRUITING
Umeå
Department of Oncology, Västerås
RECRUITING
Västerås
Switzerland
Kantonsspital Baden
RECRUITING
Baden
Spital Thurgau AG - Kantonsspital Frauenfeld
RECRUITING
Frauenfeld
Centre du sein Fribourg
RECRUITING
Fribourg
Clinique Generale-Beaulieu / Clinique de Genolier
RECRUITING
Geneva
Réseau Hospitalier Neuchâtelois (RHNe)
RECRUITING
La Chaux-de-fonds
CHUV
RECRUITING
Lausanne
Réseau du Sein Lausanne
RECRUITING
Lausanne
Kantonsspital Baselland
RECRUITING
Liestal
Kantonsspital St.Gallen
NOT_YET_RECRUITING
Sankt Gallen
Hôpital du Valais Sion
RECRUITING
Sion
Universitätsspital Zürich
RECRUITING
Zurich
ZIO AG
RECRUITING
Zurich
Contact Information
Primary
Contact for Clinical Trial Information
CTRinfo@dsi.com
908-992-6400
Time Frame
Start Date: 2023-10-24
Estimated Completion Date: 2028-09-01
Participants
Target number of participants: 1350
Treatments
Trastuzumab deruxtecan (T-DXd)
Participants with HER2-low expressing unresectable and/or metastatic breast cancer who will be treated with trastuzumab deruxtecan and part of the enrolled participants will receive conventional chemotherapy. The participants on conventional chemotherapy will be analyzed exploratory only.
Related Therapeutic Areas
Sponsors
Leads: Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company