The Efficacy and Safety of Pyrotinib, Trastuzumab Combined With Taxanes in the Treatment of Early Trastuzumab-treated HER2+ Advanced Breast Cancer (ABC).
This is a multi-center real-world study, in which patients who meet the inclusion criteria will receive treatment with Pyrotinib + Trastuzumab + Taxanes. Taxanes will be used for 6-8 cycles or discontinued due to intolerable Adverse Events (AEs), after which Capecitabine will be used for rhythmic chemotherapy combined with Pyrotinib + Trastuzumab. The aim is to explore the efficacy and safety of Pyrotinib, Trastuzumab, and Taxanes in treating Trastuzumab-treated HER2+ Advanced Breast Cancer (ABC).
• Age: 18-70 years old, female;
• Pathological examination confirmed HER-2 positive invasive breast cancer; (HER2 positivity is defined as an immunohistochemical (IHC) score of 3+ or in-situ hybridization (ISH) result for HER2 gene amplification in \>10% of immunoreactive cells.
• HER2 positivity needs to be verified by the pathology department of the research center involved in this study)
• Imaging confirmed recurrent/metastatic breast cancer;
• Patients who relapsed and metastasized three months after discontinuation of Trastuzumab treatment;
• Have at least one measurable lesion (according to RECIST 1.1 criteria);
• ECOG score of 0-2;
• Expected life span ≥3 months;
• Normal major organ function;
• The researcher believes that the participant may benefit;
⁃ Volunteer to participate in this study, sign informed consent.