68Ga-FAPI-46 PET/CT for Predicting Histological Response to Neoadjuvant Chemo-immunotherapy in Triple-negative Breast Cancer
Prospective multicenter study evaluating the prediction of histological response after neoadjuvant pembrolizumab in combination with chemotherapy by pre-treatment 68Ga-FAPI-46 PET/CT imaging in patients with early-stage high-risk TNBC.
• Female with age ≥ 18 years,
• Patients with previously untreated, non-metastatic, centrally confirmed TNBC for whom a neoadjuvant treatment with chemotherapy + pembrolizumab is the recommended option as standard of care,
• Patients with measurable targets according to RECIST/PERCIST criteria,
• Patients without distant metastasis based on staging 18F-FDG PET/CT,
• Patients with tumor tissue available,
• Patients who provided a signed written informed consent,
• Patient ability to comply with protocol requirements,
• Patients covered by a health insurance system.