Pilot Testing of Metacognitive Strategy Training to Address Cancer-related Cognitive Impairment in Breast Cancer

Status: Recruiting
Location: See location...
Intervention Type: Behavioral
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

The goal of this proposed project is to evaluate the feasibility and preliminary effect of metacognitive strategy training to improve activity performance, cognition, and quality of life in breast cancer survivors with cancer-related cognitive impairment (CRCI). The other goal of this proposed project is to examine the effects of CO-OP on resting (rsFC)- and task-state functional connectivity as compared to an inactive control group.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 20
Maximum Age: 75
Healthy Volunteers: f
View:

• self-reported CRCI (Global Rating of Cognition dysfunction as Moderately Strongly or Extremely AND a Cognitive Failures Questionnaire1 (CFQ) score \>30)

• completed treatment for active cancer diagnosis (invasive ductal or lobular BrCA Stages I, II, or III) at least 6 months but not greater than 3 years prior to participation

• able to read, write, and speak English fluently

• able to provide valid informed consent

• have a life expectancy of greater than 6 months at time of enrollment

• on stable doses (i.e., no changes in past 90 days) of medications that are known to impact cognitive function (i.e., anti-depressants)

Locations
United States
Missouri
University of Missouri
RECRUITING
Columbia
Contact Information
Primary
Anna E. Boone, PhD, OTR/L
booneae@umsystem.edu
5738827023
Backup
Juliana H. Earwood, OTD, OTR/L
jmhudson@health.missouri.edu
5738846681
Time Frame
Start Date: 2024-10-31
Estimated Completion Date: 2025-12-30
Participants
Target number of participants: 50
Treatments
Experimental: Metacognitive strategy training (MCST)
Each MCST session will be follow the procedures of Cognitive Orientation to daily Occupational Performance (CO-OP) intervention. There will be 10, 45-minute, weekly sessions. All sessions will be delivered in-person with a trained occupational therapist.
Active_comparator: Inactive Control Group
Participants will receive a weekly phone call from study staff to maintain contact and monitor changes in activity.
Related Therapeutic Areas
Sponsors
Leads: University of Missouri-Columbia
Collaborators: National Institutes of Health (NIH), National Cancer Institute (NCI)

This content was sourced from clinicaltrials.gov