Breast Cancer Clinical Trials

Find Breast Cancer Clinical Trials Near You

Hypofractionated Online Adaptive Radiotherapy of Breast Cancer

Status: Recruiting
Location: See location...
Intervention Type: Radiation
Study Type: Interventional
Study Phase: Phase 2
SUMMARY

The goal of this clinical trial is to explore the application of online adaptive radiotherapy in patients who receive moderate hypofractionated or ultrafractionated radiotherapy after breast cancer surgery. The main questions it aims to answer are: * Can online adaptive radiotherapy improve the accuracy of dose delivery? * In patients undergoing online adaptive radiotherapy, how are the treatment-related toxicities and tumor control outcomes? Participants will Receive moderate hypofractionated radiotherapy using online adaptive radiotherapy, a dose of 43.5Gy in 15 fractions or receive ultrafractionated radiotherapy using online adaptive radiotherapy, a dose of 26Gy in 5 fractions.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 35
Maximum Age: 70
Healthy Volunteers: f
View:

• Female, aged ≥35 years, \<70 years

• ECOG score: 0-2

• Having underwent breast-conserving surgery or Modified radical mastectomy with or without sentinel lymph node biopsy or axillary lymph node dissection

• Pathologically confirmed primary breast cancer

• For patients who did not receive neoadjuvant therapy: pathological staged pT0-2N0-1; for patients who received neoadjuvant therapy: staged ypT0-2N0-1

• Indicated for postoperative adjuvant radiotherapy, planned to undergo postoperative adjuvant radiotherapy

• Able to cooperate and tolerate the treatment

Locations
Other Locations
China
Peking Union Medical College Hospital
RECRUITING
Beijing
Contact Information
Primary
Xiaorong Hou, MD
hxr_pumch@163.com
+86-13811963013
Backup
Xiaorong Hou
hxr_pumch@163.com
+86-13811963013
Time Frame
Start Date: 2024-09-01
Estimated Completion Date: 2026-12
Participants
Target number of participants: 40
Treatments
Experimental: 26Gy/5f online adaptive radiotherapy
The CTV receives a dose of 26Gy in 5 fractions by online adaptive radiotherapy.
Active_comparator: 43.5Gy/15f online adaptive radiotherapy
The CTV receives a dose of 43.5Gy in 15 fractions by online adaptive radiotherapy.
Related Therapeutic Areas
Sponsors
Leads: Peking Union Medical College Hospital

This content was sourced from clinicaltrials.gov