Effect of Neoadjuvant Chemotherapy on Cardiac Function of Perioperative Patients With Breast Cancer and New Strategies for Anesthesia Response: a Multicenter, Prospective, Randomized, Controlled Study

Status: Recruiting
Location: See location...
Intervention Type: Drug
Study Type: Interventional
Study Phase: Phase 4
SUMMARY

As is well known, perioperative hemodynamic fluctuations, such as decreased blood pressure and heart rate, and cardiac dysfunction, are common complications after anesthesia. General anesthetics such as propofol and sufentanil can inhibit the central nervous system, reduce cardiac excitability and myocardial contractility, dilate peripheral blood vessels, and have a high incidence of hypotension, especially during anesthesia induction, which is particularly common in the elderly and those with underlying underlying diseases before surgery. However, the current research on the impact of neoadjuvant chemotherapy on perioperative cardiac function in patients is not specific, and there is no unified anesthesia strategy for these effects during the perioperative period. Therefore, this study aims to explore: 1. the effect of neoadjuvant chemotherapy on perioperative cardiac function in patients; 2. Improve the anesthesia plan and further explore new strategies for perioperative organ protection for such patients. The research design is a prospective, randomized, controlled trial.

Eligibility
Participation Requirements
Sex: All
Minimum Age: 18
Healthy Volunteers: f
View:

• Aged 18 and above;

• Left ventricular ejection fraction shall not be less than 45% before neoadjuvant chemotherapy and not less than 40% after neoadjuvant chemotherapy;

• The electrocardiogram shows sinus rhythm;

• Acetylsalicylic acidlevel I to III;

• Can understand and cooperate with the research process.

Locations
Other Locations
China
Fujian Medical University Affiliated Union Hospital
RECRUITING
Fuzhou
Contact Information
Primary
Zhongmeng LZM Lai, Doctor of Medicine
angerer1980@163.com
13395000771
Backup
Rongjian LRJ Li, Bachelor of Medicine
1216254452@qq.com
13328595626
Time Frame
Start Date: 2024-08-01
Estimated Completion Date: 2025-12-31
Participants
Target number of participants: 496
Treatments
Experimental: A α group
Breast cancer patients with neoadjuvant chemotherapy scheme of EC-T and selective surgery were selected, and they were intervened with norepinephrine during the perioperative period.
Experimental: B α group
Breast cancer patients with TCb neoadjuvant chemotherapy and elective surgery were selected, and they were intervened with norepinephrine during the perioperative period
Experimental: C α group
Breast cancer patients with TCbHP neoadjuvant chemotherapy and elective surgery were selected, and they were intervened with norepinephrine during the perioperative period.
Placebo_comparator: control α group
Patients with breast cancer who have not received neoadjuvant chemotherapy and who have undergone elective surgery, and who have received perioperative intervention with norepinephrine.
Experimental: A β group
Select breast cancer patients with neoadjuvant chemotherapy scheme of EC-T and elective surgery, and use normal saline for control during perioperative period.
Experimental: B β group
Breast cancer patients with TCb neoadjuvant chemotherapy and elective surgery were selected, and physiological saline was used as control during perioperative period.
Experimental: C β group
Breast cancer patients with TCbHP neoadjuvant chemotherapy and elective surgery were selected, and physiological saline was used as control during perioperative period.
Placebo_comparator: control β group
Breast cancer patients who have not received neoadjuvant chemotherapy and who have undergone elective surgery, and who use normal saline control during the perioperative period.
Related Therapeutic Areas
Sponsors
Leads: Fujian Medical University Union Hospital

This content was sourced from clinicaltrials.gov

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