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Study on Recurrent Breast Cancer and Repeated Radiation Therapy

Status: Recruiting
Location: See all (2) locations...
Intervention Type: Radiation, Procedure
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY

This study explores whether recurrent breast cancer can be safely treated with breast-conserving surgery and repeated radiation therapy in cases where patients have previously undergone radiation. Traditionally, recurrent breast cancer has been treated by removing the entire breast. However, recent research has shown that in certain situations, it may be possible to preserve the breast. The study will collect data on the safety of this treatment approach and its effects on patients. The treatment follows standard breast cancer care practices, involving 30 patients from Helsinki and Turku University Hospitals. Patients are carefully selected based on specific criteria, such as tumor size, localization, and prior treatment history. Special attention is given to the planning of radiation therapy and surgical techniques. The goal is to develop new treatment strategies that allow breast preservation even in cases of recurrent breast cancer, providing patients with high-quality and individualized care.

Eligibility
Participation Requirements
Sex: Female
Minimum Age: 55
Healthy Volunteers: f
View:

• The patient has a diagnosed breast cancer or tumor area in the breast with a maximum diameter of 3 cm, where a previous breast-conserving surgery has been performed (either invasive breast cancer or carcinoma in situ, DCIS).

⁃ The patient has only a local recurrence, and imaging studies show no suspicion of metastases outside the breast (preoperative staging N0M0).

⁃ At least 3 years have passed since the completion of prior radiation therapy. The new breast cancer can be technically treated with another breast-conserving surgery using a technique that does not require tissue transfer from areas opposite the removed tumor to restore the shape of the breast.

⁃ The patient is at least 55 years old at the time of surgery. The patient is willing to participate in the study. The patient is capable of providing informed consent.

Locations
Other Locations
Finland
Helsinki University Hospital
RECRUITING
Helsinki
Turku University Hospital
RECRUITING
Turku
Contact Information
Primary
Anselm Tamminen, MD, PhD
jlatam@utu.fi
+3583130000
Time Frame
Start Date: 2024-12-01
Estimated Completion Date: 2030-12-31
Participants
Target number of participants: 60
Treatments
Experimental: Repeat breast conserving surgery and radiotherapy Arm
The patients in this arm undergo repeat breast conserving surgery and partial breast radiotherapy
Active_comparator: Mastectomy Arm
The patients in this arm undergo mastectomy
Related Therapeutic Areas
Sponsors
Collaborators: Helsinki University Central Hospital
Leads: Turku University Hospital

This content was sourced from clinicaltrials.gov