Ultrasound-guided Bi-level Erector Spinae Plane Block and Pre-emptive Single-dose Oral Tizanidine for Postoperative Analgesia After Mastectomy Surgery: a Prospective, Randomized, Controlled Trial
Status: Recruiting
Location: See location...
Intervention Type: Procedure, Drug
Study Type: Interventional
Study Phase: Not Applicable
SUMMARY
Effective management of postoperative pain in breast cancer surgery is essential to minimize the risk of developing postmastectomy pain syndrome.The aim of this study is to evaluate the effectiveness of combining bilevel erector spinae plane (ESP) block with a single preoperative oral dose of tizanidine in improving postoperative analgesia in patients undergoing mastectomy surgery. It is hypothesized that the combination of bilevel ESP block and single-dose oral tizanidine will provide superior postoperative analgesia compared to bilevel ESP block alone in patients undergoing mastectomy.
Eligibility
Participation Requirements
Sex: Female
Minimum Age: 18
Maximum Age: 65
Healthy Volunteers: f
View:
• American Society of Anesthesiology (ASA) ІІ patients.
• Scheduled for unilateral modified radical mastectomy.
• BMI levels between 18.5- 35 Kg/m2.
Locations
Other Locations
Egypt
Oncology Centre
RECRUITING
Al Mansurah
Contact Information
Primary
Amany H ELDeeb, MD
amanyhazem91@mans.edu.eg
+2-01008479726
Time Frame
Start Date: 2025-07-15
Estimated Completion Date: 2025-12
Participants
Target number of participants: 90
Treatments
Active_comparator: Bilevel ESP block group
patients will have bilevel ESP block plus oral placebo capsule.
Active_comparator: Bilevel ESP block + tizanidine group
patients will have bilevel ESP block plus oral tizanidine capsule.
Related Therapeutic Areas
Sponsors
Leads: Mansoura University