MINIONS - Patient-specific Microstructural and radIobiological Model for persoNalised External Beam radiatION Therapy in Localised tumourS
The study will include the prospective acquisition of optimized MR imaging data of prostate and breast patients treated with radiotherapy (RT). Within the prospective study, biological specimens from patients undergoing in-room biopsy before RT, will be collected. Histological evaluation and cell culture (and organoid preparation) will be conducted, and samples/organoids will be irradiated with RT for biological validation.
• Unifocal infiltrating ductal breast carcinoma, non-special histotype
• clinical stage T1-T2,N0
• No contraindications to MRI, or metal joint prostheses from knee to shoulder included, or femoral stent.
• Patients aged \>18 years
• Good general condition (ECOG 0-2)
• Expected active treatment (crioablation or surgery or radiotherapy ).