Robustness Evaluation of Deep Inspiration Breath-Hold (DIBH) Radiotherapy Plans for Internal Mammary Irradiation in Postoperative Breast Cancer
This study is an investigator-initiated, single-arm, single-center, prospective, observational study. The hypothesis is that during the implementation of deep inspiration breath-hold (DIBH) radiotherapy plans in postoperative breast cancer patients receiving internal mammary irradiation, the actual target dose coverage and organ-at-risk (OARs) dose parameters remain within clinically acceptable ranges.
• Provide a signed and dated informed consent form (ICF) before the initiation of any trial-specific procedures.
• Female patients aged ≥ 18 years.
• Histologically confirmed invasive breast cancer.
• Have received breast-conserving surgery or mastectomy with axillary staging, including sentinel lymph node biopsy and/or axillary lymph node dissection.
• Able to hold breath for more than 30 seconds after deep inspiration.
• Planned to receive postoperative radiotherapy targeting regional lymph nodes, including the internal mammary nodes, under DIBH conditions.
• Planned to undergo moderate hypofractionated radiotherapy.
• Karnofsky Performance Status (KPS) score ≥ 80.
• The estimated life expectancy of greater than 5 years .
⁃ Sufficient wound healing from surgery, with no signs of active infection at the intended radiation site.