Finding the Invasive Haemodynamic Threshold for Symptom Relief in Stable Angina
ORBITA-FIRE is a randomised, double-blinded, placebo controlled experimental study that will identify the fractional flow reserve (FFR) and non-hyperemic pressure ratio (NHPR) thresholds that correlate with symptoms of angina for 58 patients measured invasively under experimental conditions.
• Eligibility for percutaneous coronary intervention (PCI) due to angina or angina-equivalent symptoms on exertion
• Anatomical evidence of significant single-vessel coronary stenosis defined by either:
‣ ≥70% stenosis on invasive coronary angiography (ICA)
⁃ Severe stenosis on CT coronary angiography (CTCA)
• Physiological evidence of ischaemia with a positive test on at least one of the following:
‣ Stress echocardiography
⁃ Cardiac magnetic resonance perfusion
⁃ Myocardial perfusion scintigraphy
⁃ Invasive metrics of coronary physiology